Apnea of Prematurity Clinical Trial
Official title:
Randomized Trial Investigating Four Nasal CPAP Systems in the Management of Apnea of Prematurity
The purpose of this study is to evaluate four different nasal continuous pressure systems, which are usually applied on our neonatal intensive care unit, with regard of their effect on bradycardia and desaturations in preterm infants.
BACKGROUND:
Apnea of prematurity (AOP) is a common problem in preterm infants. Nasal respiratory support
using either Continuous Positive Airway Pressure (CPAP) or Intermittent Mandatory
Ventilation (IMV) are, among others, widely used treatments. Which of the different systems
is the most efficient, however, is unclear.
OBJECTIVE:
Efficiency of different CPAP systems on reducing the cumulative percentage of bradycardia
and desaturation in preterm infants.
METHODS:
In a prospective, randomized, cross-over trial 32 preterm infants Infants will randomly
allocated to receive nasal CPAP delivered by one of the following sys-tems: (1) a
conventional IMV-System (Stephanie, Stephan GmbH, Germany with PIP 15 cmH2O, RR 10/min)
delivering CPAP via short binasal prongs (Hudson RCI, USA); (2) the Infant-Flow-System (EME
Ltd, Great Britain) with CPAP delivery via short binasal prongs; (3) the
Infant-Flow-AdvanceTM-System used in the pressure assist mode with PIP 10 cmH2O, RR 10/min;
and (4) a nasal underwater bubble CPAP with application via binasal prongs (Hudson RCI,
USA).
All systems will be adjusted to achieve an approximate PEEP of 6 cm H2O. Each study lasts 24
hours, during which chest wall and abdominal movements, SaO2, tcPCO2, ECG, esopha-gus
pressure and CPAP-/IMV-pressure will be recorded continuously. Infants will be studied in
room air in a 15° head tilt prone position while being treated with caffeine (3mg/kg/d).
PRIMARY OUTCOME MEASURE Cumulative percentage of bradycardia (heart rate <80/min) and
desaturation (SaO2 <80%) per hour.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind, Primary Purpose: Treatment
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