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The Effects Of GW679769 (Casopitant) On The Pharmacokinetics Of Docetaxel In Subjects With Cancer

Nausea and Vomiting, Chemotherapy-Induced Clinical Trial

Official title:
A Phase I, Open-Label, Randomized, Two Period Crossover Study to Investigate the Effects of GW679769 on the Pharmacokinetics of Docetaxel in Subjects With Cancer

Clinical Trial Summary

The purpose of the study is to evaluate the effect of the study drug (GW679769) on a commonly used chemotherapy drug (docetaxel) which will be given I.V. Blood samples will be taken to see if the GW679769 alters the blood levels of the chemotherapy. The study will last about 2 weeks with a final follow-up visit 6 weeks later.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Nausea and Vomiting, Chemotherapy-Induced
  • Vomiting
Clinical Trial Details
NCT number NCT00440128
Study type Interventional
Source GlaxoSmithKline
Contact
Status Completed
Phase Phase 1
Start date May 4, 2007
Completion date July 17, 2008
View Details
See also
  Status Clinical Trial Phase
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Completed NCT00431236 - A Study of the Drug Casopitant for the Prevention of Nausea Caused By Cisplatin-Based Highly Emetogenic Chemotherapy Phase 3
Completed NCT00405080 - A Study in Healthy Subjects to Assess How Dosing of Rifampin Affects What the Body Does to a Dose of GW679769 (Casopitant). Phase 1
Completed NCT00404274 - A Study Testing the Effect and Safety of Casopitant (GW679769) While Taking Warfarin in Healthy Human Volunteers Phase 1
Completed NCT00601172 - A Study Of IV Casopitant For The Prevention Of Chemotherapy Induced Nausea And Vomiting. Phase 3
Completed NCT00511823 - The Pharmacokinetic Interaction Between Oral Casopitant and Oral Dolasetron, Granisetron or Rosiglitazone in Subjects Phase 1
Completed NCT00366834 - Intravenous And Oral Casopitant (GW679769) For The Prevention Of Chemotherapy Induced Nausea And Vomiting Phase 3
Completed NCT00437229 - A Study to Assess the Safety & Interaction Between GW679769, Dexamethasone, & Ondansetron When Taken by Healthy Adults Phase 1
Completed NCT00104403 - Study Of Prevention of Chemo-Induced Nausea and Vomiting Caused By Moderately Emetogenic Chemotherapy Phase 2
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Terminated NCT00334646 - Cyclophosphamide Drug Interaction Study In Cancer Patients Phase 1
Completed NCT00460707 - A Study to Assess the Safety and Interaction Between Casopitant and Ketoconazole When Taken By Healthy Adults Phase 1