Hereditary Nonpolyposis Colorectal Cancer Clinical Trial
Official title:
Hereditary Nonpolyposis Colorectal Cancer in Taiwan-Related Genetic Study and Clinical Applications
Verified date | March 2016 |
Source | National Health Research Institutes, Taiwan |
Contact | n/a |
Is FDA regulated | No |
Health authority | Taiwan: Department of Health |
Study type | Observational |
The purpose of this study is to establish the HNPCC related information in Taiwan, and to characterize relevant susceptibility genes related to colorectal cancer to provide better disease control for the high-risk people. To accomplish this objective, we will collect detailed information of the HNPCC patients and their families from the collaborative hospitals and relate the information to the risk of CRC in order to provide sound disease control system in Taiwan.
Status | Active, not recruiting |
Enrollment | 1014 |
Est. completion date | August 2016 |
Est. primary completion date | August 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years and older |
Eligibility |
Inclusion Criteria: - Select all affected individuals. If the affected is unavailable, select the spouse and adult children (20+) of these unavailable affected individuals. - Select unaffected individuals in the following priority order: 1. study both parents of the affected individuals; 2. if parents are not available, study up to two siblings of each missing parent (if both parents are deceased, study four siblings - two from each parent); 3. study up to five unaffected siblings (age 20 or older) of the affected individual; if more than five siblings are available for study, select the siblings from oldest to youngest; 4. study up to three children (age 20 or older) of the affected individual; again, select the three oldest children if more than three are available; 5. if the two affected individuals in the multiplex family are not siblings, (first cousins, for example, then study common grandparents - if common grandparents are not available, study siblings of these grandparents) when children of the affected individual's are studied, the child's unaffected parent will also be selected for study. Exclusion Criteria: |
Observational Model: Family-Based, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Taiwan | Division of Biostatistics and Bioinformatics, National Health Research Institites | Miaoli County |
Lead Sponsor | Collaborator |
---|---|
National Health Research Institutes, Taiwan | Chang Gung Memorial Hospital |
Taiwan,
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