Cytokine Regulation of Periradicular Pain in Humans

Chronic Apical Periodontitis of Pulpal Origin Clinical Trial

Official title:

Cytokine Regulation of Periradicular Pain in Humans

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00223470
• Other study ID #: 012-1904-455
• Secondary ID: K23DE014864-01A1
• Status: Completed
• Phase: N/A
• First received: September 13, 2005
• Last updated: March 7, 2012
• Start date: October 2002
• Est. completion date: June 2008

Study information

• Verified date: March 2012
• Source: The University of Texas Health Science Center at San Antonio
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

This clinical trial evaluates the role of cytokines in patients needing root canal treatment with diagnosis of necrotic pulp and chronic apical periodontitis

Description:

This study evaluates whether periradicular exudate concentrations of cytokines differ in patients experiencing pain and mechanical allodynia due to pulpal necrosis with an acute exacerbation of a chronic apical periodontitis, as compared to patients with pulpal necrosis with chronic apical periodontitis, but no pain or mechanical allodynia

Recruitment information / eligibility

• Status: Completed
• Enrollment: 9
• Est. completion date: June 2008
• Est. primary completion date: June 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 16 Years to 60 Years

Eligibility

Inclusion Criteria:

1. Patient must be at least 16 years of age.

2. Clinical indication for Non-Surgical Root Canal Therapy (NSRCT).

3. 1st or 2nd maxillary or mandibular molar

4. Diagnosis must be Chronic Apical Periodontitis (CAP) with or without symptoms.

5. Intact, mature apices.

6. ASA I or II

Exclusion Criteria:

1. Failure to meet any of the above

2. Previous NSRCT

3. Previous pulpotomy or pulpectomy

4. Suppurative apical periodontitis

5. Patients taking medications which can affect their pain rating or medications which effect their immune system ( such as glucocorticoids)

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Chronic Apical Periodontitis of Pulpal Origin
• Periapical Periodontitis
• Periodontitis

Locations

Country	Name	City	State
United States	Univerity of Texas Health Science Center at San Antonio	San Antonio	Texas

Sponsors (3)

Lead Sponsor	Collaborator
The University of Texas Health Science Center at San Antonio	National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)

Country where clinical trial is conducted

United States,