The Efficacy of Imipramine in Treatment of Refractory Functional Dyspepsia

Functional Gastrointestinal Disorder Clinical Trial

Official title:

The Efficacy of Imipramine in Treatment of Functional Dyspepsia: A Double Blind Randomized Placebo Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00164775
• Other study ID #: DA Study
• Status: Completed
• Phase: Phase 3
• First received: September 9, 2005
• Last updated: September 14, 2016
• Start date: June 2005
• Est. completion date: August 2010

Study information

• Verified date: September 2016
• Source: Chinese University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Health authority: Hong Kong: Department of Health
• Study type: Interventional

Clinical Trial Summary

The aim of this study is evaluate the efficacy of Imipramine, a tricyclic antidepressant, in treatment of functional dyspepsia. This is a double blind randomised placebo controlled trial in which consecutive patients with diagnosis of functional dyspepsia will be studied. After exclusion of organic cause of dyspepsia by endoscopy, these patients will be randomly assigned to either imipramine or placebo. All the patients will enter an additional 4 weeks of drug withdrawal phase after the initial 12 weeks of study drug treatment. They will be evaluated for treatment response, which is defined as satisfactory relief of dyspeptic symptoms at the end of 12-week treatment.

Description:

Functional dyspepsia is a heterogeneous disorder that consists of a variety of upper gastrointestinal symptoms such as postprandial fullness, early satiety, pain, bloating, belching, or nausea. The pathophysiology of functional dyspepsia is not fully understood and the correlation of those proposed mechanisms with the clinical characteristics and treatment response is poor. Owing to the poor understanding on the mechanism, treatment of functional dyspepsia has been far from satisfactory. There are numerous modalities of medical treatment that has been reported to be effective but the results are conflicting. Large and well-controlled studies in functional dyspepsia have shown that proton pump inhibitor had a therapeutic gain of about 10%-15% better than placebo in patients with functional dyspepsia. However, this positive effect was restricted to patients with reflux-like dyspepsia, a subgroup that actually is no longer considered to belong to functional dyspepsia. Prokinetic agent is another class of drug that has been widely used in functional dyspepsia. Although recent reviews suggest that prokinetics are more effective than placebo, most trials were flawed with significant heterogeneity among studies. Tricyclic antidepressant (TCA) is another important class of drug that is commonly used in various functional gastrointestinal disorders (FGID) and chronic pain disorders. The effectiveness of TCA in FGID has been supported by a meta-analysis, which reported that improvement in global GI symptoms against placebo was highly significant. The mechanism of TCA in treatment of FGID is poorly understood but the therapeutic effect is evident even in low dose, suggesting that it is independent of its anti-depressive action. To date, clinical trial of TCA in treatment of FD with sufficient sample size and well-defined clinical endpoint is still lacking. So the objective of this study is to evaluate the efficacy of imipramine, a tricyclic antidepressant, in treatment of functional dyspepsia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 107
• Est. completion date: August 2010
• Est. primary completion date: August 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients fulfill the diagnostic criteria of functional dyspepsia as defined by Rome II criteria

• Age > 18 years old

• Failure of treatment response to PPI, H2 receptor antagonist fo 8 weeks and domperidone for 4 weeks

Exclusion Criteria:

• Organic pathology detected by endoscopy

• GERD or IBS as dominant compliant

• Presence of any alarm symptom: anemia, recurrent vomiting, weight loss

• Concomitant Helicobacter pylori infection

• Concomitant use of neuroleptic or antidepressant, NSAID

• Previous gastrointestinal surgery

• Cardiac arrhythmia, untreated glaucoma or benign prostate hypertrophy

• Pregnancy

• Known hypersensitivity or contraindication for tricyclic antidepressant

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Digestive System Diseases
• Dyspepsia
• Functional Gastrointestinal Disorder
• Gastrointestinal Diseases

Intervention

Drug:
• Imipramine
25mg nocte for first 2 weeks then 50 mg nocte for 10 weeks
• Placebo
One tab nocte for first 2 weeks then 2 tabs for 10 weeks

Locations

Country	Name	City	State
Hong Kong	Prince of Wales Hospital	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
Chinese University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Overall satisfactory relief (Global Symptom Assessment) at 12 weeks	It is defined as a response of "Yes" to the question: "Do you experience overall satisfactory relief of dyspeptic symptom with the current treatment?" by global symptom assessment.	12 weeks	No
Secondary	Individual dyspeptic symptom scores	8-item dyspepsia symptom score questionnaire assessing epigastric pain, epigastric burning, postprandial fullness, early satiety, belching, bloating, nausea, and vomiting on a scale of 0-3 over the last 7 days	12 weeks	No
Secondary	Days of sleep disturbance	Effect on sleep will be assessed by asking patients if they had insomnia on =1 day per week	12 weeks	No
Secondary	Mood assessment	Effect on mood will be assessed using the hospital anxiety and depression scale (HADS)	12 weeks	No