Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00052364
Other study ID # NCI-2012-02830
Secondary ID PHII-36N01CM1710
Status Completed
Phase Phase 2
First received January 24, 2003
Last updated June 17, 2013
Start date September 2002

Study information

Verified date June 2013
Source National Cancer Institute (NCI)
Contact n/a
Is FDA regulated No
Health authority United States: Food and Drug Administration
Study type Interventional

Clinical Trial Summary

Phase II trial to study the effectiveness of oxaliplatin in treating patients who have unresectable, recurrent or metastatic liver cancer. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.


Description:

Read more »
Read more »

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms

  • Adult Primary Hepatocellular Carcinoma
  • Advanced Adult Primary Liver Cancer
  • Carcinoma, Hepatocellular
  • Liver Neoplasms
  • Localized Unresectable Adult Primary Liver Cancer
  • Recurrent Adult Primary Liver Cancer

Intervention

Drug:
oxaliplatin
Given IV
Other:
laboratory biomarker analysis
Correlative studies

Locations

Country Name City State
United States City of Hope Duarte California

Sponsors (1)

Lead Sponsor Collaborator
National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Response rate evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST) Confidence intervals for the response rate will be established by calculating exact 95% confidence limits for a binomial parameter. Up to 6 years No
Primary Time to progression Up to 6 years No
Secondary Duration of overall survival Estimated using the product-limit method of Kaplan and Meier. Up to 6 years No
Secondary Progression-free survival Estimated using the product-limit method of Kaplan and Meier. Up to 6 years No
See also
  Status Clinical Trial Phase
Terminated NCT00787787 - Sunitinib Malate and Capecitabine in Treating Patients With Unresectable or Metastatic Liver Cancer Phase 2
Completed NCT01229111 - Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers Phase 2
Completed NCT00107536 - Lapatinib Ditosylate in Treating Patients With Unresectable Liver or Biliary Tract Cancer Phase 2
Completed NCT02072356 - Radiolabeled Glass Beads in Treating Patients With Liver Cancer That Cannot be Removed by Surgery Early Phase 1
Completed NCT00604721 - Selumetinib in Treating Patients With Locally Advanced or Metastatic Liver Cancer Phase 2
Completed NCT00101036 - Lapatinib in Treating Patients With Locally Advanced or Metastatic Biliary Tract or Liver Cancer That Cannot Be Removed By Surgery Phase 2
Completed NCT00028496 - Vaccine Therapy With or Without Sargramostim in Treating Patients With Advanced or Metastatic Cancer Phase 1
Completed NCT01766219 - CPI-613 in Treating Patients With Advanced or Metastatic Bile Duct Cancer That Cannot Be Removed By Surgery Phase 1/Phase 2
Terminated NCT00427973 - AZD2171 in Treating Patients With Locally Advanced Unresectable or Metastatic Liver Cancer Phase 2
Completed NCT00321594 - Belinostat in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery Phase 1/Phase 2
Terminated NCT00087191 - EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer N/A
Completed NCT00006016 - Thalidomide and Chemoembolization With Doxorubicin in Treating Patients With Liver Cancer That Cannot be Removed by Surgery Phase 2
Completed NCT01643499 - Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies Phase 1
Completed NCT00639509 - IMC-A12 in Treating Patients With Advanced Liver Cancer Phase 2
Completed NCT00083226 - Doxorubicin and Bortezomib in Treating Patients With Liver Cancer Phase 2
Completed NCT00033462 - Erlotinib in Treating Patients With Unresectable Liver, Bile Duct, or Gallbladder Cancer Phase 2
Completed NCT01666756 - Chinese Herbal Formulation PHY906 and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer Phase 1
Active, not recruiting NCT02119065 - Pilot Study to Assess Lung Shunting of Yttrium-90 Microspheres Using PET/CT
Recruiting NCT02557503 - Hepatic Arterial Infusion of Oxaliplatin and Fluorouracil Treatment of Advanced Primary Liver Cancer After TACE Phase 4
Withdrawn NCT01859182 - Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced Gallbladder or Bile Duct Cancer That Cannot Be Removed By Surgery Phase 2