Leukemia, Myelocytic, Acute, Pediatric Clinical Trial
Official title:
A Phase II, Open Label Study of Clofarabine in Pediatric Patients With Refractory or Relapsed Acute Myelogenous Leukemia
| Verified date | March 2015 |
| Source | Sanofi |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | United States: Food and Drug Administration |
| Study type | Interventional |
Clofarabine (injection) is approved by the Food and Drug Administration (FDA) for the
treatment of pediatric patients 1 to 21 years old with relapsed acute lymphoblastic leukemia
(ALL) who have had at least 2 prior treatment regimens.
The purpose of this study is to determine whether Clofarabine is safe and effective in the
treatment of Acute Myelogenous Leukemia (AML.)
| Status | Completed |
| Enrollment | 40 |
| Est. completion date | August 2004 |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | N/A to 21 Years |
| Eligibility |
Inclusion Criteria: - Have a diagnosis of AML according to FAB classification with greater than or equal to 25% blasts in the bone marrow. - Be less than or equal to 21 years old at time of initial diagnosis. - Not be eligible for therapy of higher curative potential, and must be in first or subsequent relapse and/or refractory. Where an alternative therapy has been shown to prolong survival in an analogous population, this should be offered to the patient prior to discussing this study. - Patients with acute promyelocytic leukemia (M3) must have been treated with at least 2 regimens-a retinoic acid-containing regimen and an arsenic trioxide-containing regimen before being considered for this study. - Have a Karnofsky Performance Status (KPS) of greater than or equal to 70. - Provide signed, written informed consent from parent or guardian and assent from patients greater than or equal to 7 years old according to local IRB and institutional requirements. - Have adequate organ function as indicated by the following laboratory values, obtained within 2 weeks prior to registration: Serum bilirubin less than or equal to 1.5 x ULN; AST and ALT less than or equal to 5 x ULN; Serum Creatinine less than 2 x ULN for age. ULN= Institutional Upper Limit of Normal Exclusion Criteria: - Received previous treatment with Clofarabine. - Have an active, uncontrolled systemic infection considered opportunistic, life threatening, or clinically significant at the time of treatment. - Are pregnant or lactating. Male and female patients who are fertile must agree to use an effective means of birth control (i.e., latex condom, diaphragm, cervical cap, etc) to avoid pregnancy. - Have psychiatric disorders that would interfere with consent, study participation, or follow up. - Are receiving any other chemotherapy. Patients must have been off previous therapy for at least 2 weeks (with the exception of intrathecal therapy, which is allowed up to 24hrs prior to 1st dose of study drug) and must have recovered from acute toxicity of all previous therapy prior to enrollment. Treatment may start earlier, following consultation with the ILEX Medical Monitor, if there is evidence of disease relapse prior to that time. - Have any other severe concurrent disease, which, in the judgment of the investigator, would make the patient inappropriate for entry into this study. - Have symptomatic CNS involvement. - Febrile neutropenia at time of study entry. - Known or suspected fungal infection (ie. patients on parenteral antifungal therapy). |
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Country | Name | City | State |
|---|---|---|---|
| United States | Johns Hopkins Children's Center | Baltimore | Maryland |
| United States | Children's Memorial Hospital | Chicago | Illinois |
| United States | Children's Medical Center | Dallas | Texas |
| United States | Children's Hospital | Denver | Colorado |
| United States | Cook's Children's Medical Center | Fort Worth | Texas |
| United States | University of Connecticut Health Center | Hartford | Connecticut |
| United States | Texas Children's Cancer Center | Houston | Texas |
| United States | The University of Texas M.D. Anderson Cancer Center | Houston | Texas |
| United States | Arkansas Children's Hospital | Little Rock | Arkansas |
| United States | Children's Hospital | Los Angeles | California |
| United States | St. Jude Children's Research Hospital | Memphis | Tennessee |
| United States | Memorial Sloan-Kettering | New York | New York |
| United States | University of Nebraska Medical Center | Omaha | Nebraska |
| United States | Children's Hospital | Orange County | California |
| United States | Children's Hospital | Philadelphia | Pennsylvania |
| United States | Children's Hospital | Pittsburgh | Pennsylvania |
| United States | Children's Hospital | San Diego | California |
| United States | Children's Hospital | St. Louis | Missouri |
| Lead Sponsor | Collaborator |
|---|---|
| Genzyme, a Sanofi Company |
United States,
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00125840 -
Clofarabine in Adult Patients With Advanced Solid Tumors
|
Phase 1 |