Systemic Lupus Erythematosus Clinical Trial
OBJECTIVES:
I. Determine the induction of durable remission in patients with life-threatening systemic
lupus erythematosus or antiphospholipid antibody syndrome treated with cyclophosphamide.
II. Determine the toxicity of this drug in these patients.
PROTOCOL OUTLINE:
Patients receive cyclophosphamide IV on days 1-4 and filgrastim (G-CSF) beginning on day 10
and continuing until blood counts recover.
Patients are followed monthly for 6 months, and then every 3 months thereafter.
;
Allocation: Non-Randomized, Primary Purpose: Treatment
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