Leukemia Clinical Trial
Official title:
Allogeneic Bone Marrow Transplantation for Patients With Chronic Myelogenous Leukemia in the Chronic Phase or Multiple Myeloma
RATIONALE: Bone marrow transplantation may be able to replace immune cells that were
destroyed by the chemotherapy or radiation therapy that was used to kill cancer cells.
PURPOSE: Phase II trial to study the effectiveness of allogeneic bone marrow transplantation
in treating patients who have multiple myeloma, chronic phase chronic myelogenous leukemia,
or agnogenic myeloid metaplasia.
OBJECTIVES:
- Determine the efficacy of allogeneic bone marrow transplantation (BMT) following
high-dose cyclophosphamide and total body irradiation in patients with multiple
myeloma, agnogenic myeloid metaplasia, or chronic myelogenous leukemia in first or
second chronic phase.
- Determine the efficacy of BMT following busulfan and cyclophosphamide in these
patients.
- Determine the toxic effects of these preparative regimens in these patients.
OUTLINE: Patients are stratified by remission (first vs second vs third).
Patients who have not undergone prior radiotherapy receive cyclophosphamide IV on days -6
and -5 and then undergo total body irradiation twice a day on days -4 to -1. Allogeneic bone
marrow is infused on day 0.
Patients who have undergone prior radiotherapy receive oral busulfan every 6 hours on days
-7 to -4 or -6 to -3 and cyclophosphamide IV over 2 hours on days -3 and -2. Allogeneic bone
marrow is infused on day 0.
Patients are followed at days 30 and 90, at 6 months, and then annually thereafter.
PROJECTED ACCRUAL: A total of 20-30 patients will be accrued for this study within 2 years.
;
Primary Purpose: Treatment
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