Prevalence and Associated Factors of Sarcopenia Among Elderly Patients in Osteoporosis Clinic

Osteoporosis Clinical Trial

Official title:

Prevalence and Associated Factors of Sarcopenia Among Elderly Patients in Osteoporosis Clinic

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05688150
• Other study ID #: KHRehab_LeungHC_1
• Status: Completed
• Start date: June 20, 2022
• Est. completion date: February 28, 2023

Study information

• Verified date: February 2024
• Source: Kowloon Hospital, Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This was a cross-sectional study. Patients who attended the osteoporosis clinic of Kowloon Hospital from June to December 2022 were recruited. Grip strength and appendicular skeletal muscle mass index were measured with a Jamar dynamometer and a bioimpedance analyser. Since most patients in our clinic are of Chinese ethnicity, the diagnostic criteria in the Consensus Update on Sarcopenia Diagnosis and Treatment by the Asian Working Group for Sarcopenia in 2019 was utilised. The diagnosis of sarcopenia was established by the presence of both low grip strength (Male: < 28 kg, Female < 18 kg) and low appendicular skeletal mass (Male: < 7.0 kg/m2, Female: < 5.7 kg/m2)

Recruitment information / eligibility

• Status: Completed
• Enrollment: 94
• Est. completion date: February 28, 2023
• Est. primary completion date: December 12, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Patients aged 60 years old or above
• Diagnosed with osteoporosis by: Fragility fracture or T-score =-2.5 SDs at any site on DXA scan and;
• Able to read and write Chinese

Exclusion Criteria:

• Unable to maintain standing posture for bioimpedance analysis
• Modified Functional Ambulation Classification (MFAC) = IV
• Incompetent in giving consent
• Unable to follow instructions
• Implanted with metal in any of four limbs
• Implanted with pacemaker, implantable cardioverter defibrillator or any other types of electrical device

Related Conditions & MeSH terms

• Osteoporosis
• Sarcopenia

Locations

Country	Name	City	State
Hong Kong	Kowloon Hospital	Kowloon

Sponsors (1)

Lead Sponsor	Collaborator
Kowloon Hospital, Hong Kong

Country where clinical trial is conducted

Hong Kong, 

References & Publications (1)

Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc. 2020 Mar;21(3):300-307.e2. doi: 10.1016/j.jamda.2019.12.012. Epub 2020 Feb 4. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prevalence of Sarcopenia	The diagnosis of sarcopenia would be established by the co-existence of low grip strength and low appendicular skeletal muscle mass.	June - December 2022
Primary	Grip strength	Grip strength would be measured with Jamar digital dynamometer.	June - December 2022
Primary	Appendicular Skeletal Muscle Mass Index	Appendicular Skeletal Muscle Mass Index would be measured with bioimpedance analyzer.	June - December 2022
Secondary	Association between BMI and Sarcopenia.	BMI would be measured on clinic attendance.	June - December 2022
Secondary	Association between Frailty and Sarcopenia.	Clinical Frailty Scale would be documented in clinical consultation.	June - December 2022
Secondary	Association between Charlson Comorbidities Index and Sarcopenia	Components of Charlson Comorbidities Index would be extracted from medical record.	June - December 2022
Secondary	Association between Bone Mineral Densities and Sarcopenia	Bone mineral densities of spine and neck of femur would be extracted from the report of dual-energy X-ray absorptiometry.	June - December 2022