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Study Evaluating Denosumab on Vascular and Bone Metabolism in Osteoporotic Chronic Kidney Disease (HDENOBS) — HDENOBS  

Osteoporosis Clinical Trial

Official title:
Observational Study Evaluating the Effect of a Biotherapy Treatment (Anti- RANKL Ligand Antibody: Denosumab) on Bone and Vascular Metabolism in Osteoporotic Chronic Kidney Disease Patients

Clinical Trial Summary

Aim of this study is to evaluate in a population of osteoporotic chronic kidney disease patients the effect of denosumab: - on coronary artery calcification scores evolution after 24 months of followup - on abdominal aorta calcification scores evolution after 24 months of followup - on bone mineral density (femoral T-score) at 24 months - on bone mineral density evolution (femoral T-score) after 24 months of follow-up - on bone mineral density evolution (lumbar T-score) after 24 months of follow-up - on parameters of bone remodelling after 24 months of follow-up - on cardiovascular morbidity (cardiovascular events) and mortality after 24 months of follow-up - the tolerance after 24 months of follow-up

Clinical Trial Description

Aim of this study is to evaluate in a population of osteoporotic chronic kidney disease patients the effect of denosumab: - on coronary calcification scores evolution (by multidetector computed tomography) after 24 months of follow-up - on abdominal aorta calcification scores evolution (by plain abdominal Xray) after 24 months of follow-up - on bone mineral density (femoral T-score) (by bone densitometry) at 24 months - on bone mineral density evolution (femoral T-score) (by bone densitometry) after 24 months of follow-up - on bone mineral density evolution (lumbar T-score) (by bone densitometry) after 24 months of follow-up - on parameters of bone remodelling after 24 months of follow-up - on cardiovascular morbidity (cardiovascular events) and mortality after 24 months of follow-up - the tolerance after 24 months of follow-up ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05234047
Study type Observational
Source University Hospital, Montpellier
Contact Jean-Paul CRISTOL, MD, PhD
Phone +33 467 338315
Email jp-cristol@chu-montpellier.fr
Status Not yet recruiting
Phase
Start date May 2022
Completion date February 2025
View Details
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