Osteoporosis Clinical Trial
Official title:
Impact on Bone Health in Patients Undergoing Radical Cystectomy: Prevalence of Osteoporosis, Trabecular Bone Score (TBS) Assessment and Fracture Risk by FRAX in Male Patients After One Year of Radical Cystectomy
Radical cystectomy is associated with a greater risk of fracture due to long-term metabolic
consequences of intestinal urinary diversions. One of the mechanisms theoretically involved
with bone loss after radical cystectomy is metabolic acidosis that inhibits osteoblast
activity, stimulates osteoclast bone resorption and urinary calcium loss. Other factors as
advanced age, diabetes or chronic renal failure may increase the effect of metabolic
acidosis. Moreover, osteoporosis in men remains under-diagnosed and under-appreciated.
Although metabolic and bone changes after radical cystectomy are well known, bone mineral
density (BMD) or fracture risk assessment are not recommended in different international
guidelines during follow-up.
The objective of this study is to evaluate the fracture risk of male patients undergoing
radical cystectomy after more than one year of follow-up. Fracture risk assessment will be
performed by BMD to analyse the prevalence of osteoporosis, vertebral fractures and
measurement of Trabecular Bone Score (TBS) in combination with the Fracture Risk Assessment
Tool (FRAX). These results will be correlated with blood markers with the objective to
determine independent risk factors for osteoporosis or bone fracture in this population.
To the best of the investigator's knowledge this will be the first study assessing the
fracture risk after radical cystectomy performance evaluating BMD and the probability of
fracture at 10 years using the FRAX algorithm.
n/a
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