Osteoporosis Clinical Trial
Official title:
Effects of Denosumab Therapy for Japanese Osteoporotic Patients
In this study, the investigators would like to analyze the bone mineral density (BMD) , bone
turnover makers, and fracture prevention effects of denosumab in Japanese patients under
clinical practice. The participants are treated in the investigators hospital, who are under
severe osteoporotic condition.
The main objective of this study is to investigate effects of denosumab. The researchers
also investigate the effects of Effects of previous osteoporotic therapy to denosumab
treatment. In this study, the investigators analyse the determinants of subsequent BMD
increase and fracture preventing effect by teriparatide.
Registry criteria: Patients treated in the investigators hospital using denosumab. Enrolled
patients are severe osteoporosis; more than two previous osteoporotic fractures, low BMD (<
young adult mean 65%).
Interventions: blood analyses and dual-energy X-ray absorptiometry (DXA) every 4 months
Informed consent: Written informed consent will be obtained. Sample size: Five-hundreds
participants
;
Observational Model: Case-Only, Time Perspective: Prospective
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