Osteoporosis Clinical Trial
Official title:
"Levels of RANKL and OPG in Gingival Crevicular Fluid of Patients With Post-menopausal Osteoporosis / Osteopenia and Periodontal Disease."
The aim of this study was to investigate the levels of RANKL and Osteoprotegerin, and their
relationship in gingival crevicular fluid of post-menopausal women with
osteoporosis/osteopenia and chronic periodontitis simultaneously and evaluate the effect
that the use of bisphosphonates in periodontal disease.
Study hypothesis:
"The osteoporosis / osteopenia in postmenopausal women patients with periodontal disease
affect the ratio RANKL / OPG in gingival crevicular fluid samples favoring
osteoclastogenesis processes "
81 active periodontal sites from 31 postmenopausal women aged 45-70 years with chronic
periodontitis were studied. Samples of gingival crevicular fluid were collected by paper
strips and ELISA test was conducted to determine the total concentration of RANKL, OPG, and
then obtain the values of the RANKL / OPG ratio. We analyzed 66 samples of gingival
crevicular fluid obtained from active periodontal sites of 17 patients with osteopenia /
osteoporosis and 15 samples gingival crevicular fluid obtained from active periodontal sites
obtained of 14 controls patients with normal osseous condition.
Statistical analyzes were computed and analyzed using Graphpad Software. To determine if the
data correspond to a normal distribution the D'Agostino-Pearson test was used. The values of
cytokines (RANKL and OPG) and its ratio (RANKL / OPG) were compared using Mann-Whitney Test
t U. Analysis Spearman correlation and linear regression for statistic was also performed to
determine whether there was any relationship between the variables analyzed. It was
considered as statistically significant p value ≤ 0.05.
;
Observational Model: Case Control, Time Perspective: Cross-Sectional
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT06287502 -
Efficacy of Structured Exercise-Nutritional Intervention on Sarcopenia in Patients With Osteoporosis
|
N/A | |
| Completed |
NCT03822078 -
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Denosumab (AMG 162) in Japanese Postmenopausal Women
|
Phase 1 | |
| Recruiting |
NCT05845021 -
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
|
N/A | |
| Completed |
NCT00092066 -
A Study to Evaluate the Safety, Tolerability, and Efficacy of an Investigational Drug and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227)
|
Phase 3 | |
| Recruiting |
NCT04754711 -
Interest of Nutritional Care of Children With Sickle Cell Disease on Bone Mineral Density and Body Composition
|
N/A | |
| Completed |
NCT04736693 -
Replication of the HORIZON Pivotal Fracture Trial in Healthcare Claims Data
|
||
| Not yet recruiting |
NCT06431867 -
Primary Care Management of Osteoporosis in Older Women
|
||
| Completed |
NCT02922478 -
Role of Comorbidities in Chronic Heart Failure Study
|
||
| Recruiting |
NCT02635022 -
Fragility Fracture Liaison Service and Anti-osteoporosis Medication Monitoring Service Study
|
||
| Recruiting |
NCT02616627 -
Association Between DXA Results and the Complications, Clinical Courses and Outcomes in Chronic Dialysis Patients
|
||
| Active, not recruiting |
NCT02617303 -
Prevention of Falls and Its Consequences in Elderly People
|
N/A | |
| Completed |
NCT02566655 -
Clinical Trial of Intravenous Infusion of Fucosylated Bone Marrow Mesenchyme Cells in Patients With Osteoporosis
|
Phase 1 | |
| Completed |
NCT02559648 -
Denosumab vs Placebo in Patients With Thalassemia Major and Osteoporosis
|
Phase 2 | |
| Completed |
NCT03420716 -
Symbiotic Yogurt, Calcium Absorption and Bone Health in Young Adult Women
|
N/A | |
| Not yet recruiting |
NCT02223572 -
Secondary Fracture Prevention in Patients Who Suffered From Osteoporotic Fracture
|
N/A | |
| Completed |
NCT02003716 -
DeFRA Questionnaire as an Anamnestic Form
|
N/A | |
| Not yet recruiting |
NCT01854086 -
Compliance and Persistence With Osteoporosis Treatment and Attitude Towards Future Therapy Among Post-menopausal Israeli Women During Drug Treatment or Drug Holiday
|
N/A | |
| Unknown status |
NCT01913834 -
Nasally and sc Administered Teriparatide in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT02143674 -
Muscle Strengthening Exercises and Global Stretching in Elderly
|
N/A | |
| Completed |
NCT01757340 -
Calorie Restriction With Leucine Supplementation
|
N/A |