Effects of Yoga on Bone Metabolism in Premenopausal Women

Osteoporosis Clinical Trial

Official title:

Effects of an 8-month Yoga Intervention on Bone Metabolism in Healthy Middle-aged Premenopausal Women: A Randomized Controlled Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02163668
• Other study ID #: OUYogaStudy
• Status: Completed
• Phase: N/A
• First received: June 9, 2014
• Last updated: June 13, 2014
• Start date: September 2009
• Est. completion date: April 2012

Study information

• Verified date: June 2014
• Source: University of Oklahoma
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

This study examined the effects of 8 months of Yoga training on bone density and bone turnover markers in premenopausal women, ages 35-50 years. The style of Yoga used was power Yoga that involved postures with a jumping component. The investigators hypothesized that the Yoga intervention would result in beneficial improvements in bone turnover markers, by increasing the bone formation marker and decreasing the bone resorption marker.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 47
• Est. completion date: April 2012
• Est. primary completion date: June 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 35 Years to 50 Years

Eligibility

Inclusion Criteria:

• participants had not been engaged in resistance training or in Yoga exercise for at least 12 months prior to the study

• did not have chronic back or joint problems or cardiovascular disease

• not taking antihypertensive drugs or any medication that affects bone density

• not taking hormonal contraception

• they self-reported having regular menstrual cycles.

Exclusion Criteria:

• body weight more than 300 pounds

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Bone Health
• Osteoporosis

Intervention

Other:
• Yoga Group
8 months of Yoga training

Locations

Country	Name	City	State
United States	Department of Health and Exercise Science, University of Oklahoma	Norman	Oklahoma

Sponsors (1)

Lead Sponsor	Collaborator
University of Oklahoma

Country where clinical trial is conducted

United States, 

References & Publications (2)

Chan K, Qin L, Lau M, Woo J, Au S, Choy W, Lee K, Lee S. A randomized, prospective study of the effects of Tai Chi Chun exercise on bone mineral density in postmenopausal women. Arch Phys Med Rehabil. 2004 May;85(5):717-22. — View Citation

Phoosuwan M, Kritpet T, Yuktanandana P. The effects of weight bearing yoga training on the bone resorption markers of the postmenopausal women. J Med Assoc Thai. 2009 Sep;92 Suppl5:S102-8. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in bone mineral density from baseline to 8 months		pre and post 8 months training	No
Primary	change in bone turnover markers		pre and post 8 month intervention	No
Primary	change in tibia bone characteristics	changes in volumetric bone mineral density and bone strength of the non-dominant tibia assessed by peripheral Quantitative Computed Tomography (pQCT)	pre and post 8 month intervention	No
Primary	Changes in muscular strength	Isotonic 1 repetition maximum (1RM) for 4 lower body and 2 upper body resistance exercises	pre and post 9 month intervention	No
Primary	Change in arterial compliance	Arterial compliance of the large and small arteries was assessed using Pulse Contour analysis.	pre and post 8 month interventon	No
Primary	Change in Insulin-like Growth Factor-1 (IGF-I) and Insulin-like Growth Factor BP3 (IGFBP3)		pre and post 8 month intervention	No
Secondary	Daily Calcium intake	Calcium intake is a potential confounding variable. Participants were encouraged to increase their calcium intakes if found to be low before the intervention began.	pre and post 8 month intervention	No
Secondary	Menstrual History	This information was used to monitor menstrual characteristics to ensure they were still premenopausal at the post test.	pre and post 8 month intervention	No
Secondary	Dietary intake	Three day dietary logs were recorded by participants before the exercise intervention. They were analyzed for caloric intake and nutrient composition using the Diet Analysis Plus 9 software.	At baseline at the same time as other outcomes, about 2 weeks before the beginning of the yoga training	No
Secondary	Change in physical activity levels	Physical activity levels estimated by the bone-specific physical activity (PA) questionnaire to monitor their PA outside of the intervention	pre and post 8 month intervention	No
Secondary	Change in body composition		pre and post 8 month intervention	No