Osteoporosis Clinical Trial
Official title:
Acute and Chronic Effects of Whole-body Vibration on Mobility, Muscle Strength, Bone and General Health Status in the Frail Elderly
Objective: To study the acute and chronic effects of whole-body vibration (WBV) exercises on
the lower extremity blood flow, mobility function, balance, muscle strength, bone density,
and general health status, and its feasibility as an intervention in frail elderly patients.
Design: Randomized controlled trial. Subjects: The frail older persons meeting the Fried
Frailty Criteria.
Interventions: All eligible subjects were randomly assigned to 4 groups:
(1) WBV group: Subjects received a whole-body vibration exercise alone; (2) Progressive
resistance training (PRT) group: Subjects received progressive resistance training; (3) WBV+
PRT group: Subjects received the whole-body vibration and progressive resistance training;
(4) Control group: Subjects received no intervention/training. The periods of intervention
are 12 weeks.
Main measures: The lower extremities blood flow (the diameters and red blood cell velocity
of the common femoral artery), timed up and go test, 30-second chair stand test, five times
sit to stand test, lower extremities muscle strength, balance function, balance confidence,
bone density, and general health status was assessed at the beginning of the study, at
instant, 12 weeks and 24 month after the intervention.
Study hypothesis: Whole-body vibration exercise is a safe and effective method that can
improve the lower extremity blood flow, mobility function, balance, muscle strength, bone
density, and general health status in the frail elderly.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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