Osteoporosis Clinical Trial
Official title:
Epidemiological, Observational, Multicenter Clinical Trial
Osteoporosis is the most common disease of bone and characterized firstly by low bone mass and secondly, impaired bone microarchitecture structure resulting in reduced strength and increased risk of fracture. Osteoporosis is divided into: primary (Postmenopausal Osteoporosis Osteoporosis & elderly and senile osteoporosis) and secondary. The most common form is postmenopausal osteoporosis. It occurs in women after menopause and is associated with decreased estrogen production, which normally occurs at this age women Osteoporosis usually occurs after age 50, it is very common in women than in men, and its frequency increases with advancing age.
According to the findings of epidemiological studies in different countries, osteoporosis
affects 25-35% of women and 15-20% of men aged 50 and over. In terms of our country in the
recent nation-epidemiological research on rheumatic diseases in the general adult
population, ie persons aged 19 and over, organized and conducted by the Greek Institute of
Rheumatology Research, became a separate study on frequency of osteoporosis in women aged 50
years and above. These women was measured BMD at the lumbar spine and at the upper end of
the femur and found that 28.4% of Greek women aged 50 and over have osteoporosis. It is
indeed very interesting finding in this study that women who have osteoporosis, the vast
majority, ie about 75%, I do not know. This is of particular importance and highlights the
need to educate and inform systematically the public, especially women regarding both the
modern possibilities for early diagnosis of osteoporosis, and for the implementation of
primary and secondary prevention.
Osteoporosis is a major public health problem for two reasons: First, because it is common,
and secondly because it has significant impact on patients and their families, the health
system and the national economy.
The main clinical manifestation of osteoporosis is fractures low energy, ie fractures
occurring after mild degree injury, eg fall from a standing position. Approximately 40% of
cases osteoporotic fractures on the vertebrae, 20% in the femoral neck, 20% to 20% radius
and several other bones. While osteoporosis is generally regarded as a disease of women,
however, as already mentioned above, osteoporosis affects and men. It has even been found
that 30% of osteoporotic fractures of the femoral neck and 20% of osteoporotic vertebral
fractures occur in men.
The risk of fractures of the hip, vertebrae and radius increases with advancing age in both
women and men. It has even been estimated that the risk of osteoporotic fracture in women
aged 50 and over is 40-50% and 15-20% in men.
The adverse effects of osteoporosis patients and their families, the health system and the
national economy due to fractures. Indicative only some of these effects:
- The mortality in patients with hip fractures and clinically symptomatic vertebral
fractures is significantly higher than that observed in individuals of the same sex and
similar age in the general population. For example, within the first year after the
fracture approximately 20% of patients with hip fracture and 25% of patients with
vertebral fracture die.
- One year after a hip fracture, only 50% of patients can execute without help ordinary
activities of everyday life.
- On an annual basis the number of days of hospitalization for patients with osteoporotic
fractures is significantly greater than the number of days of hospitalization required
for patients with stroke or diabetes mellitus or myocardial infarction or breast
cancer.
Moreover, in 2000 the European Union the then 15 Member States (total population of
379,000,000 people) is estimated to have occurred 3.79 million osteoporotic fractures and
that the direct costs of these fractures (costs of hospitalization, surgery and medical
care) was approximately 32 billion Euros.
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Time Perspective: Prospective
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