Osteoporosis Clinical Trial
Official title:
The Effect of 16 Weeks of Hip Adduction and Abduction Resistance Exercise Training on Strength and Density of the Proximal Femur
Performing adduction and abduction resistance exercise will increase hip bone density and
strength to a greater extent than doing squat and deadlift exercise.
Aim #1: To determine if doing hip adduction and abduction resistance exercise training for 16
weeks improves spine bone mineral density and hip bone mineral density and strength as
determined by finite element modeling.
Aim #2: To compare the effects of hip adduction and abduction exercise to squat and deadlift
exercise with respect to potential changes in hip bone mineral density and strength.
Aim #3: To determine if the addition of adduction and abduction exercise to squat and
deadlift exercise promotes an "additive" effect with respect to changes in spine bone mineral
density and hip bone mineral density and bone strength.
The investigators will carry out a 16-week exercise training study (n=24) consisting of 3
groups (n=8 per group) of healthy, non-resistance trained adult men and women (age 25-55
years). Our aim is to determine if hip adduction and abduction resistance exercise is more
effective than squat and deadlift exercise with respect to changes in the whole bone strength
and density of the proximal femur and spine.
Group A will do only hip adduction and abduction exercises. Group B will do only squat and
deadlift exercise Group C will do a combination of hip adduction and abduction and squat and
deadlift exercise
Subjects will be imaged with quantitative computed tomography (QCT) of the proximal femur and
spine, pre-training and post-training, to determine changes in spinal bone density and
proximal femoral bone density and strength.
Serum assays of bone formation (osteocalcin) and bone resorption (serum CTX type I) will be
performed four times during the study at 4 week intervals.
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