A Study To Evaluate The Effects Of Repeat Dosing Of Esomeprazole On The Pharmacokinetics Of SB-751689 In Healthy People

Osteoporosis Clinical Trial

Official title:

An Open-Label Study to Evaluate the Effects of Repeat Dosing of Esomeprazole on the Pharmacokinetics of SB-751689 in Healthy Adult Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00508534
• Other study ID #: CR9106339
• Status: Completed
• Phase: Phase 1
• First received: July 26, 2007
• Last updated: May 15, 2009
• Start date: July 2007
• Est. completion date: August 2007

Study information

• Verified date: May 2009
• Source: GlaxoSmithKline
• Contact: n/a
• Is FDA regulated: No
• Health authority: Singapore: Health Sciences AuthorityUnited States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

This study will examine the effects of altering gastric pH in healthy volunteers on the pharmacokinetics of SB-751689 with or without food.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: August 2007
• Est. primary completion date: August 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 21 Years to 55 Years

Eligibility

Inclusion Criteria:

• Healthy adult males or females between the ages of 21 and 55, inclusive, will be eligible for the study. Female subjects must be of non-childbearing potential including pre-menopausal females with documented (medical report verification) hysterectomy or bilateral oophorectomy or postmenopausal defined as 12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum FSH levels > 40 mIU/ml or 6 weeks postsurgical bilateral oophorectomy with or without hysterectomy.

• The subject has a body mass index (BMI) of 19 to 31 kg/m2 where BMI= (weight in kg)/(height in meters)2

• Subjects must be genotyped as poor metabolizers or heterozygous extensive metabolizers for CYP2C19.

• The subject is capable of giving informed consent, which includes compliance with the requirements and restrictions listed in the consent form.

Exclusion Criteria:

• Genotyped homozygous extensive metabolizers for CYP2C19 (Section 6.1.1 CYP2C19 Polymorphism Genotyping).

• Any clinically relevant abnormality identified on the screening history and physical or laboratory examination, 12-lead electrocardiogram (ECG) and/or 24 hour Holter, including QTc > or = 450 msec.

• Positive urine drug screen at screening.

• Positive urine test for alcohol at pre-dose.

• Positive for HIV at screening

• Chronic hepatitis B and C, as evidenced by positive Hepatitis B surface antigen or Hepatitis C antibody.

• Urinary cotinine levels indicative of smoking at screening.

• History of smoking or use of nicotine containing products within one year of the study or >10 pack-year history of smoking overall.

• History of regular alcohol consumption exceeding 7 units/week for women and 14 units/week for men (1 unit = 5 ounces of wine or 12 ounces of beer or 1.5 ounces of hard liquor) within 6 months of screening.

• History of drug abuse within 6 months of the study.

• The subject has participated in a clinical trial and has received a drug or a new chemical entity with 30 days or 5 half-lives, or twice the duration of the biological effect of any drug (whichever is longer) prior to the first dose of the current study medication.

• Exposure to more than four new chemical entities within 12 months prior to the first dosing day.

• Use of prescription or nonprescription drugs including antacids, including vitamins, herbal and dietary supplements (including St. John's Wort) within 7 days or (14 days if the drug is a potential enzyme inducer or 5 half-lives, whichever is longer) prior to the first dose of study medication, unless, in the opinion of the Investigator and Sponsor, the medication will not interfere with the study procedures or compromise subject safety.

• Consumption of red wine, grapefruit, grapefruit juice or grapefruit-containing products within 14 days prior to the first dose of study medication.

• Donation of blood in excess of 500 mL within 56 days prior to dosing.

• Evidence of renal, hepatic or biliary impairment

• History of serious gastrointestinal disease

• History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the physician responsible, contraindicates their participation.

• History of clinically significant cardiovascular disease.

• History of pernicious anemia, pancreatitis, osteosarcoma or kidney stones.

• Medical conditions which might alter bone metabolism.

• Liver function tests (ALT, AST, GGT, alkaline phosphatase, total bilirubin) and/or parathyroid hormone (PTH) test or CPK outside the reference range at screening.

• Males unwilling to refrain from fathering a child during the study and for 14 days following the last dose of study medication.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Osteoporosis

Intervention

Drug:
• SB-751689

Locations

Country	Name	City	State
Singapore	GSK Investigational Site	Singapore

Sponsors (1)

Lead Sponsor	Collaborator
GlaxoSmithKline

Country where clinical trial is conducted

Singapore, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cmax and AUC of SB-751689 alone or after treatment with esomeprazole, and under fasted or fed conditions		over 1 week
Secondary	Adverse event report, ECGs, vital signs, laboratory test, and clinical monitoring		over a week