Osteoporosis Clinical Trial
The purpose of this study is to determine whether the serum levels of certain calcium-binding proteins may be helpful in the diagnosis and management of metabolic bone diseases.
Osteoporosis is an important and costly health issue. The diagnosis of the disease is based
on measurement of bone mineral density or the occurrence of characteristic fractures.
Currently it is not possible to predict fractures in individual patients, and the ability to
monitor the response to treatment is limited as well.
We have synthesized and characterized a novel photoreactive Ca2+-analog reagent, Azido
ruthenium (AzRu) that binds covalently to Ca2+-binding sites in proteins. The specificity of
AzRu for Ca2+-binding proteins, its photoactivation and its radioactive labeling pave the
way for a wide use of AzRu as a powerful tool to assess Ca2+-dependent cellular processes,
both in vitro and in vivo. Using radiolabeled AzRu, it will be possible to identify
Ca2+-binding proteins in a biological sample such as whole cell, isolated mitochondria, ER
or other protein containing fractions. Protein bound [103Ru]AzRu in biological sample can be
separated by SDS gel electrophoresis, followed by Coomassie staining and exposure of the
dried gel to X-ray film (autoradiography). This allows the identification of the [103Ru]
radiolabeled proteins. The labeled protein bands can be cut from the gel and subjected to
MALADI-TOF analysis and the identity of the protein can be determined by a sequence homology
search.
These would allow detection of Ca2+-binding proteins in the serum of various diseases and
disorders, potentially leading to identification of novel biomarkers for disease
diagnostics.
We would like to use blood samples to carry out the procedure described above for
identification of Ca2+ binding proteins appearing or their level is increased in disease or
under pathogenic conditions. Since Ca2+ binding proteins play an important role in bone
metabolism, we chose to test their occurrence in the serum of patients with osteoporosis and
other metabolic bone diseases.
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Time Perspective: Cross-Sectional
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