Vitamin D Administration in the Nursing Home

Osteoporosis Clinical Trial

Official title: Intermittent Vitamin D Administration in the Nursing Home: Impact on Vitamin D Status, Falls, Bone Turnover and Bone Density

Status Completed

Clinical Trial Summary

Administration of vitamin D 50,000 units once monthly will:

• Maintain serum 25-OH vitamin D above 20 ng/ml

• Reduce falls

• Increase calcaneal BMD

• Reduce bone turnover

• Be well tolerated: volunteers will not develop hypercalcemia

• Improve performance on a swallowing quality of life questionnaire

Clinical Trial Description

1. Research questions: We propose a prospective double-blind, randomized, placebo-controlled trial of once-monthly vitamin D oral capsules (50,000 units) in nursing-home residents.

Subjects from several Wisconsin nursing homes were randomized to receive once-monthly vitamin D oral capsules (50,000 units) or placebo. Blood levels of 25-OH D, parathyroid hormone, serum calcium, and a marker of bone turnover will be measured periodically by standard lab assays. Swallowing quality of life was measured by questionnaire. Appropriate statistical tests (paired T tests, 95% confidence intervals will be calculated with the large sample approximation for binomial variables, other). ;

Related Conditions & MeSH terms

• Osteoporosis
• Vitamin D Deficiency

• NCT number: NCT00204919
• Study type: Interventional
• Source: University of Wisconsin, Madison
• Status: Completed
• Phase: N/A
• Start date: June 2001
• Completion date: November 2004