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Sequential Therapies After Osteoanabolic Treatment — START  

Osteoporosis, Postmenopausal Clinical Trial

Official title:
Efficacy of Sequential Therapies After Osteoanabolic Treatment in Postmenopausal Women With Severe Osteoporosis: the Sequential Treatment After Romosozumab and Teriparatide (START) Study

Clinical Trial Summary

12-month prospective, open-label, multicenter, international, observational study evaluating sequential treatments after osteoanabolics

Clinical Trial Description

Caucasian women with severe postmenopausal osteoporosis who have completed their course with romosozumab or teriparatide will be assigned to one of the following 3 options: i) zoledronate 5mg infusion or ii) denosumab subcutaneous injections or iii) teriparatide (for those previously treated with romosozumab) or romosozumab (for those previously treated with teriparatide). Endpoints: Primary: BMD changes at the lumbar spine at 12 months. Secondary: i) BMD changes at the non-dominant femoral neck and total hip at 12 and 24 months; ii) changes at levels of bone turnover markers throughout the study; iii) incident fractures: vertebral (clinical and morphometric identified on VFA scans) and non-vertebral ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06164795
Study type Observational
Source 424 General Military Hospital
Contact Athanasios D Anastasilakis, PhD
Phone 2310381431
Email a.anastasilakis@gmail.com
Status Recruiting
Phase
Start date November 25, 2023
Completion date December 2025
View Details
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