Mechanisms of Anabolic Osteoporosis Therapy

Status Recruiting

Clinical Trial Summary

The aim of this study is to investigate the effect of romosozumab on bone cells during early and late phases of treatment.

Clinical Trial Description

The investigators will perform paired iliac crest bone biopsies in postmenopausal women who meet standard romosozumab treatment indications and are being prescribed romosozumab by their treating physician. All study volunteers will have a bone biopsy procedure prior to starting therapy, and then an identical procedure at the contralateral side either 3-6 weeks ("early") or 6-8 months ("late") after starting therapy. This is not a randomized clinical trial testing the efficacy of a drug - the investigators will not be assigning volunteers to a specific osteoporosis therapy, though the investigators will randomize volunteers to either the early or late second biopsy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05688969
Study type	Interventional
Source	Massachusetts General Hospital
Contact	Mackenzie Jordan
Phone	617-726-6129
Email	MRJORDAN@mgh.harvard.edu
Status	Recruiting
Phase	N/A
Start date	June 14, 2023
Completion date	December 2028

View Details

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