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Osteolysis clinical trials

View clinical trials related to Osteolysis.

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NCT ID: NCT06309433 Recruiting - Clinical trials for Periprosthetic Osteolysis

Assessment of Periprosthetic Bone Mineral Density in Patients Undergoing Total Knee Prosthesis of Different Design

DXA-TKA
Start date: August 30, 2023
Phase: N/A
Study type: Interventional

compare changes in BMD via DXA at the level of the femoral and tibial periprosthetic bone between two groups of patients undergoing cemented TKA of different design (posterior stabilization vs posterior cruciate preservation) with proms at a 2-year follow-up.

NCT ID: NCT06041828 Not yet recruiting - Dental Implants Clinical Trials

Regular Home-use Dual Light Photodynamic Therapy in the Prevention of Osteolysis After Dental Implant Surgery

Start date: June 2, 2024
Phase: N/A
Study type: Interventional

The aim of the study is to determine whether regular use of the antibacterial, photodynamic, CE-marked Lumoral device reduces the risk of osteolysis after dental implant surgery. The study also aims to find out whether Lumoral treatment can replace the use of chlorhexidine. Subjects will be randomized into two groups (20 + 20 subjects) and all will be given individual guidance on maintaining good oral hygiene. The participants in the study group will also be given Lumoral appliances with instructions for use at home. The Lumoral device has been shown in previous studies to be safe to use and effective in eliminating harmful oral bacteria.

NCT ID: NCT05018130 Recruiting - Complication Clinical Trials

Bio-Integrative Versus Metallic Screws for Calcaneus Osteotomies

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

The use of bio-integrative implants in orthopedic surgery is growing exponentially. As many biomechanical and histological studies were able to sustain its structural and biological properties, few clinical studies are available to support its advantages, such as good osteosynthesis, lower rates of removal, and diminished implant-related artifact in imaging studies. This information is vital to providers when choosing the proper material and planning postoperative treatment. This trial intends to test the capacity of the bioabsorbable screws in reaching the same clinical and radiographical outcomes of the current metallic screws.

NCT ID: NCT04255966 Active, not recruiting - Clinical trials for Arthroplasty Complications

Plasmafit® Revision Structan® Hip Endoprosthesis Cup

Start date: April 12, 2021
Phase:
Study type: Observational

The aim of this observational study is to collect clinical and radiological results of the new Plasmafit® Revision Structan® Hip Endoprosthesis Cup in a standard patient population and when used in routine clinical practice.

NCT ID: NCT03692351 Completed - Clinical trials for Arthroplasty Complications

Osteolysis Development Around Uncemented Cups With or Without Screw Holes

Start date: June 15, 1994
Phase: N/A
Study type: Interventional

In order to investigate the role of acetabular cup screw holes for the transport of osteolysis-inducing particles in a total hip arthroplasty articulation, the investigators compare the amount of bone loss around acetabular cups with and without holes. Bone loss is measured with computed tomography at 7 years and 15 - 18 years of follow-up.

NCT ID: NCT02299817 Active, not recruiting - Osteolysis Clinical Trials

Denosumab for Treating Periprosthetic Osteolysis.

Start date: August 2015
Phase: Phase 2
Study type: Interventional

The main objective is to study the efficacy of denosumab in reducing wear-induced osteolysis around uncemented acetabular implants used in total hip arthroplasty. Patients included in the study will receive the same dose of 60 mg denosumab or placebo (1 ml solution) for a total of 6 doses with start on day one and every 6 months with last treatment at 30 months. The primary endpoint will be the change in volume of the osteolytic lesion over 3 years measured (measured with 3D-CT in cm³).

NCT ID: NCT01464645 Terminated - Osteolysis Clinical Trials

Post-Market Study of the Modular Revision Hip System

MRHS
Start date: January 2012
Phase:
Study type: Observational

The purpose of this study is to examine the short term efficacy of the MRH system as well as determine if operating room time is decreased using this simple, two-tray system.

NCT ID: NCT01422642 Completed - Osteoarthritis Clinical Trials

Do We Need High-Flexing Total Knee Arthroplasty to Improve the Survivorship and to Decrease the Incidence of Osteolysis?

Start date: January 2001
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if there are any clinical or ROM differences in total knee arthroplasty with standard NexGen LPS prosthesis and NexGen LPS-Flex prosthesis.

NCT ID: NCT01272830 Completed - Synovitis Clinical Trials

Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint Replacements

Apatone-B
Start date: October 2010
Phase: Phase 2
Study type: Interventional

This research study is being conducted to determine if taking oral (by mouth in pill form) Apatone®B (a combination of Vitamins C and K3) will reduce chronic joint discomfort and improve function of non-infected symptomatic postoperative total joint replacements.

NCT ID: NCT01198457 Completed - Multiple Myeloma Clinical Trials

Study to Investigate Adherence of Patients to Clodronate (Bonefos) Treatment

BONA
Start date: January 2009
Phase: N/A
Study type: Observational

Adherence (or compliance with) a medication regimen is generally defined as the extent to which patients take medication as prescribed by their health care providers. The adherence to medications has close relation to effectiveness of the therapy. The primary objective of this study is to observe the adherence to treatment with oral clodronate (PDC, proportion of days covered, number of days in which clodronate is taken according to treating physician recommendation) in patients with malignancy. The secondary "hypothesis generating" objective is to describe the relation between adherence to treatment with oral clodronate and efficacy of the therapy (skeletal events, pain).