Osteoarthrosis Clinical Trial
Official title:
Effect of Preoperative Intravenous High Dose Methylprednisolone on Immune Signaling in Patients Scheduled for Total Hip-arthroplasty
The study evaluates the pathophysiological effects of a single dose Methylprednisolone
administered prior to total hip-arthroplasty (THA) surgery. The investigators examine the
effect on immune signaling and recovery after surgery.
Half of participants will receive intravenous Solu-Medrol 125 mg, while the other half will
receive placebo.
The investigators hypothesize that the group receiving Methylprednisolone will experience a
positive modulation of the immune response and an enhanced recovery.
The anti-inflammatory effects of glucocorticoids are well known. The beneficial effects on
postoperative pain, postoperative nausea and vomiting are well-documented.
Hip-arthroplasty surgery and the inflammatory stress response in general affect the
potential of recovery. The basic physiological mechanisms behind restoration of recovery
after surgery are still unresolved. The many different immune cells involved in the complex
signal response enables wound healing and recovery, and the individual immune signal pattern
might be able to predict recovery. The effects of glucocorticoids on this immune signal
pattern is unknown and calls for further investigation.
The study is to be considered as exploratory. This study is embedded in a primary study
registrated as: NCT02445898
For further details please view the EudraCT registration:
EudraCT nr.: 2015-000102-19
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