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NCT05593640 Clinical Trial

Thromboxane A2 and Osteoarthritis

Osteoarthritis Clinical Trial

Official title:
Throboxane Effect on Chondrocytes; Role in Osteoarthritis

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05593640
Other study ID # 22Rhumato03
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date September 1, 2022
Est. completion date September 2023

Study information
Verified date October 2022
Source Centre Hospitalier Universitaire de Nice
Contact Christian ROUX, MD, PhD
Phone +33492035491
Email roux.c2@chu-nice.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

TXA2 inhibits the expression of the primary marker of thermogenesis (UCP1) while prostacyclin (PGI2), another metabolite derived from arachidonic acid, enhances its expression. Given the close relationship between the adipocyte and the chondrocyte, the study team hypothesises that thromboxane A2 controls chondrocyte formation and function and thus cartilage homeostasis. The study objectives are: i) to analyse the role of TXA2 on chondrocyte differentiation in vitro, ii) to determine the association between circulating and tissue TXA2 levels in a rat model of osteoarthritis, and iii) to correlate circulating and synovial fluid levels of TXA2 with the development of osteoarthritis in a small human cohort. The proposed research aims to better understand the mechanisms underlying the role of lipid metabolites in chondrocyte formation and function, paving the way for the development of nutritional and pharmacological therapies to combat OA and associated metabolic disorders.

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date September 2023
Est. primary completion date September 2023
Accepts healthy volunteers No
Gender All
Age group 40 Years and older
Eligibility Inclusion Criteria: - presence of knee osteoarthritis with effusion, , no inflammatory disease Exclusion Criteria: - anticoagulant treatment - inflammatory disease

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• biological samples
blood and synovial liquid will be sampled

Locations
Country Name City State
France CHU de NICE NICE Cedex 1

Sponsors (2)
Lead Sponsor Collaborator
Centre Hospitalier Universitaire de Nice French Society of Rheumatology

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary to look for correlation between the rate of throboxane and the grade of osteoarthritis kellgren and lawrence classification 6 months
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