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Clinical Trial Summary

This randomized controlled trial aims to investigate if metformin has osteoarthritis protective effects among overweighted knee osteoarthritis patients. The co-primary outcomes are changes in tibiofemoral cartilage volume and Western Ontario and McMaster Universities Arthritis Index (WOMAC) from baseline to month 24. The secondary outcomes are changes in visual analog scale (VAS)-assessed knee pain, tibiofemoral cartilage defect, effusion-synovitis volume, and tibiofemoral bone marrow lesion from baseline to month 24.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05034029
Study type Interventional
Source Guangzhou First People's Hospital
Contact
Status Active, not recruiting
Phase N/A
Start date August 1, 2021
Completion date December 31, 2024

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