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Investigation of Oxidative Markers and Antioxidant Defense in Female Patients With Osteoarthritis

Osteoarthritis Clinical Trial

Official title:
Investigation of Oxidative Markers and Antioxidant Defense in Female Patients With Osteoarthritis

Clinical Trial Summary

Osteoarthritis has a multifactorial etiology: aging, genetic, sex, weight, alimentation, injuries, infections etc. The objective of the study is to investigate the eating behaviour of the patients included in the study by using a semiquantitative questionnaire (frequency and quantity) by estimating the foods that are known to be protective for osteoarthritis (vegetables, fruits, cereals) as the ones that are considered risk factors (meat origin, refined fats). Also, the oxidative-antioxidative balance will be evaluated by determining markers: oxidated glutathione/reducted glutathione, catalase enzyme, superoxide dismutase, glutathion peroxidase and malonyldialdehyde.

Clinical Trial Description

A total of 300 patients with osteoarthritis will be included in the study. The objective of the study is to investigate the eating behaviour of the patients included in the study by using a semiquantitative questionnaire (frequency and quantity) by estimating the foods that are known to be protective for osteoarthritis (vegetables, fruits, cereals) as the ones that are considered risk factors (meat origin, refined fats). Also, the weight and height of each patient will be assessed and the patients will be included in 4 classes based on the body mass index: underweight, normal weight, overweight and obese. The type of physical activity will also be noted and the oxidative-antioxidative balance will be evaluated by determining serum markers: oxidated glutathione/reducted glutathione, catalase enzyme, superoxide dismutase, glutathion peroxidase and malonyldialdehyde. Correlation between eating behaviour, body mass index and oxidative stress markers will be made. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04206462
Study type Observational
Source Iuliu Hatieganu University of Medicine and Pharmacy
Contact Rodica A Ungur, MD, PhD
Phone 0040507021
Email rodica.ana.ungur@gmail.com
Status Recruiting
Phase
Start date July 17, 2019
Completion date June 2020
View Details
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