Crucumin Effects on the Immune System in Osteoarthritis Patients

Status Recruiting

Clinical Trial Summary

In this study, the effects of crucumin on cellular and humoral immune system in patients with osteoarthritis will be investigated. Concentration of CXCL8, April, CX3CL1 and IL-17 will be evaluated with ELISA. TH-1, TH-17, TReg and Ly.B cells count will be measured by Flowcytometry. MicroRNA-720, MicroRNA-155, MicroRNA-16 and MicroRNA-146a gene expression will be measured with Real Time PCR technique.

Clinical Trial Description

The purpose of this study was to evaluate the effect of the active ingredient of crucumin on the reduction of symptoms of osteoarthritis. Of the 30 patients participating in this study, a blood sample will be taken at the beginning of the study, and then after three months of taking the crucumin. To evaluate the response to treatment, after each person sampling, we will analyze cell count for Th-1, Th-17, TReg and Ly.B by flowcytomtry method. Also we will measure cytokines level of IL-17, CXCL8, CX3CL1 and April by ELISA method. Finally we evaluate the gene expression of MicroRNA-720, MicroRNA-155, MicroRNA-146a and MicroRNA-16 by Real Time PCR technique. ;

Study Design

Related Conditions & MeSH terms

Osteoarthritis

Clinical Trial Details

NCT number	NCT03715140
Study type	Interventional
Source	Mashhad University of Medical Sciences
Contact	Mojgan Mohammadi, Ph.D
Phone	0098 51 38012762
Email	mozhganmohammadi69@yahoo.co.uk
Status	Recruiting
Phase	Phase 3
Start date	May 1, 2019
Completion date	December 30, 2020

View Details

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