Osteoarthritis Clinical Trial
Official title:
Randomized Controlled Trial of Exercise Therapy in Combination With Central Nervous System-targeted Treatment Compared With Exercise Therapy Alone for Treatment of People With Knee Osteoarthritis
The aim of this study is to investigate if exercise therapy comprising the NEMEX program in combination with a CNS-targeted treatment using GMI and SDT is superior to exercise therapy alone in improving self-reported pain, function, quality of life and objective measures related to hyperexcitability of the CNS (e.g. central sensitization) in people with KOA.
Participants will be randomized to one of two treatments initiated after randomization: the
NEMEX program combined with a CNS-focused protocol or the NEMEX program alone.
The NEMEX program will consist of 12-weeks of individualized and supervised exercise sessions
applied twice weekly (n=24 sessions). Each exercise session will last approximately 60minutes
and include three parts: warming up, a circuit program and cooling down.
The CNS-targeted treatment will consist of 12-week individualized and supervised sessions
applied twice weekly. Each training session will last approximately 30 minutes and include
three parts, which are further explained below: 1) discussion of the participant's knee pain
experience from a pain neuroscience perspective, 2) graded SDT and 3) GMI training.
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