Osteoarthritis Clinical Trial
Official title:
Impact of Comorbidities on Measure of Indirect Utility Change in Hip and Knee Ostearthritis
National cohort study aimed to investigate the impact of comorbidities (number and type of comorbidities) on health utility state change in lower lim osteoarthritis (hip and knee OA).
The concept of health utility state was developed by economists to explain individual
choices and preferences for health states. It is expressed as the "desirability or
preference that individuals exhibit for the condition". This health utility state can be
measured indirectly using health-relation quality of life questionnaires.
Chronic diseases such as OA are known to be associated with impairment of quality of life.
Given that OA prevalence increases with age, OA is often associated with other diseases
(comorbidities). A cross-sectional study showed that comorbidities are associated with lower
health utility state in OA. Investigation of longitudinal impact of comorbidities on health
utility state change is need.
Main objective: Determine the impact of comorbidities on change in health utility state
among patients with lower limb OA.
Secondary objective: Determine the Minimal Clinically important Difference in health utility
state among patients with lower limb OA.
The COMUTAR study uses longitudinal data from the Knee and Hip Osteoarthritis Longitudinal
Assessment (KHOALA) cohort study. Health utility state is measured indirectly using Medical
Outcome Study Short Form-36 quality of life questionnaire Comorbidities are assessed using
the Functional Comorbidity Index
;
Observational Model: Case-Only, Time Perspective: Prospective
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