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Safety and Efficacy of Autologous SVF Cells in Treating Patients With Osteoarthritis

Osteoarthritis Clinical Trial

Official title:
A Self-control Study: Safety and Efficacy of Autologous Adipose-Derived SVF Cells Delivered Intra-articularly in Patients With Osteoarthritis

Clinical Trial Summary

it's a self-control, double blind study of autologous adipose-derived stromal vascular fraction (SVF) to treat 50 osteoarthritic knees of grade II or III (K-L scale) under IRB-approved protocol in a feasibility and safety study.

Clinical Trial Description

The adipose-derived SVF was obtained through disaggregation of lipoaspirate and resuspension of the SVF in 2 ml saline, with at least 50 million nucleated SVF cells and a mean viability of 85%, injected per single knee and the other knee treated with placebo.

Cell suspension and placebo will be injected using ultrasound guidance. Safety and knee function will be evaluated by questionaires monthly and MRI in every three months post-op. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02846675
Study type Interventional
Source Shanghai East Hospital
Contact
Status Completed
Phase Phase 1/Phase 2
Start date November 1, 2014
Completion date January 31, 2018
View Details
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