Pharmacological Treatment In Osteoarthritis — FABIO  

Osteoarthritis Clinical Trial

Official title: Pharmacological Treatment In Osteoarthritis

Status Completed

Clinical Trial Summary

The purpose of this study is to determine the efficacy of hydroxychloroquine in hand osteoarthritis.

Clinical Trial Description

Osteoarthritis is the most common joint disease, most frequently involving the hands, resulting in pain, stiffness and loss of hand function. At present, there is no option to prevent the onset or the progression of hand osteoarthritis (OA). It is believed that inflammation plays an important role in the pathogenesis of OA and that anti-inflammatory drugs might be an effective treatment for OA. Anti-malarial agents like chloroquine and hydroxychloroquine are potential anti-inflammatory drugs and hydroxychloroquine has already proven to be an effective suppressor of inflammation in rheumatoid arthritis. Several previous studies with hydroxychloroquine in hand OA also showed a possible effect on pain and inflammation, but these studies were mostly retrospective with a small number of patients. This is the first prospective, randomised, placebo-controlled study to determine the effect of hydroxychloroquine in hand osteoarthritis. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Osteoarthritis

• NCT number: NCT01148043
• Study type: Interventional
• Source: Maasstad Hospital
• Status: Completed
• Phase: Phase 3
• Start date: July 2010
• Completion date: September 2014