Evaluation of Pain Level Reduction After Low-dose Radiation in Symptomatic Facet Joint Arthritis — LORAFA  

Lower Back Pain Chronic Clinical Trial

Official title: Evaluation of Pain Level Reduction After Low-dose Radiation in Symptomatic Facet Joint Arthritis - A Prospective Randomized Clinical Trial.

Status Recruiting

Clinical Trial Summary

The goal of this clinical trial is to compare low-dose radiation therapy (LDRT) with intra-articular steroid injections in participants suffering from chronic lower back pain as cause of facet joint arthritis (FJA).

The main question[s] it aims to answer are:

• Is LDRT non-inferior to intra-articular steroid injections in terms of pain reduction

• Is there a difference in long-term pain reduction between LDRT and intra-articular steroid injections Participants will be randomly assigned to one of the two treatment groups.

Clinical Trial Description

However, there has been no published study providing scientific evidence by prospective randomized data on the effect of LDRT in patient suffering from facet osteoarthritis. LDRT seems a viable treatment method with anti-inflammatory potential and possible long-lasting benefit in pain resolution for patients with facet joint arthritis (FJA), which can prevent from an ultimate surgical treatment.

The rationale of this trial is to generate scientific evidence that LDRT is an alternative non-invasive treatment option for FJA, whose primary outcome "pain reduction" is equivalent to the most common treatment intra-articular steroid injections. ;

Related Conditions & MeSH terms

• Low Back Pain
• Lower Back Pain Chronic
• Osteoarthritis
• Osteoarthritis, Spine

• NCT number: NCT05852808
• Study type: Interventional
• Source: Kantonsspital Aarau
• Contact: Silvia Gomez Ordonez, Dr. med.
• Phone: +41 62 838 02 15
• Email: silvia.gomezordonez@ksa.ch
• Status: Recruiting
• Phase: N/A
• Start date: October 31, 2023
• Completion date: August 2025