Osteoarthritis of the Knee Clinical Trial
Official title:
Viscosupplementation in Patients With Severe Osteoarthritis of the Knee
A comparison of intraarticular administration of Hylan GF20, Triamcinolone and both associated in patients with severe osteoarthritis of the knee with follow up of one, three and six months.
The objective of this research is to evaluate the short-term results of viscosupplementation
in patients with advanced osteoarthritis of the knee.
There is a bigger demand of patients requiring total knee arthroplasty than the number of
surgeries performed by the Unified Health System in Brazil. For this reason the queues to
perform this surgery are huge and time-consuming in the referral hospitals. Whereas all
these patients are suffering from severe pain and limiting, and awaiting the surgery for a
few years, it is necessary to try any treatment, even if temporary, to ease the pain and
suffering of those patients.
A double-blind randomized prospective study will be held at Hospital Federal dos Servidores
do Estado do Rio de Janeiro, with patients from the waiting list for Total Knee Arthroplasty
who accept to participate and sign the informed consent form. Will be selected the last 150
knees in TKA queue. Patients will be randomized and divided in 3 groups of 50 knees. A group
will be submitted to an intraarticular injection of corticosteroid (1 ml of sterile
Triamcinolone Hexacetonide solution 20 mg/ml). A second group will be subjected to
administration of 6 ml of Hylan GF20. The third group will receive Hylan GF20 associated
with corticosteroid (7 ml solution containing 1 ml of triamcinolone and 6 ml of Hylan GF20).
The injection technique will be the same for all patients. The outcome results will be
measured by a form with patient data, functional scores (Knee Society Score and Lysholm)
before treatment and at one, three and six months after treatment.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03277066 -
A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis
|
Phase 2 | |
Completed |
NCT02556710 -
A Study to Evaluate the Efficacy & Safety of an Intra-Articular Ampion Injection for Pain of Osteoarthritis of the Knee
|
Phase 3 | |
Withdrawn |
NCT02237846 -
Clinical Study of Umbilical Cord Tissue Mesenchymal Stem Cells (UC-MSC) for Treatment of Osteoarthritis
|
Phase 1/Phase 2 | |
Completed |
NCT02242435 -
A Multiple Injection Study Evaluating Safety and Efficacy of Ampion in Osteoarthritis
|
Phase 3 | |
Completed |
NCT02096393 -
Patient Specific Instrumentation in TKR
|
N/A | |
Completed |
NCT01849445 -
Targeted Rehabilitation to Improve Outcome After Knee Replacement- A Physiotherapy Study
|
N/A | |
Completed |
NCT01704157 -
A Prospective Study Evaluating the Treatment of Knee Osteoarthritis With the Cryo-Touch III Device
|
N/A | |
Active, not recruiting |
NCT01374230 -
Long-Term Multicenter Evaluation of the E1® Tibial Bearing
|
N/A | |
Completed |
NCT02156440 -
Cross-over Study of the Efficacy and Safety of SierraSil Joint Formula 14 in Osteoarthritis of the Knee
|
Phase 2 | |
Not yet recruiting |
NCT01270412 -
Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis
|
Phase 2/Phase 3 | |
Completed |
NCT01410409 -
Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement
|
N/A | |
Completed |
NCT01207115 -
A Study of ABT-652 in Adults With Osteoarthritis Pain of the Knee
|
Phase 2 | |
Completed |
NCT00988091 -
Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee
|
Phase 3 | |
Completed |
NCT00970008 -
Exploring Massage Benefits for Arthritis of the Knee
|
Phase 2 | |
Completed |
NCT01331278 -
A Comparative Study of Knee Systems
|
Phase 4 | |
Completed |
NCT00792727 -
HKT-500 in Adult Patients With Osteoarthritis (OA) Knee Pain
|
Phase 3 | |
Completed |
NCT00531427 -
Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee
|
Phase 3 | |
Completed |
NCT00449696 -
Gel-200 Versus Placebo in Osteoarthritis of the Knee
|
Phase 3 | |
Completed |
NCT04145011 -
Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain
|
N/A | |
Completed |
NCT01430559 -
Effect Of Meloxicam Versus Placebo In Mainland Chinese Patients With Osteoarthritis Of The Knee
|
N/A |