Osteoarthritis of the Knee Clinical Trial
The purpose of this study is to assess the efficacy of a single dose level of gefapixant
(AF-219/MK-7264) in subjects with moderate to severe pain associated with osteoarthritis (OA)
of the knee compared with placebo after 4 weeks of treatment.
The study will also assess the safety and tolerability, changes in physical function,
stiffness, treatment response and health outcomes.
Subjects who satisfy entry criteria at Screening will enter the Washout Phase, discontinuing
their current nonsteroidal anti-inflammatory drug (NSAID) therapy.
Up to 220 subjects who fulfill flare (and other entry) criteria will be randomized to
gefapixant or placebo.
Subjects will complete Treatment Visits 1, 2, 3, and 4 weeks after starting study drug. At
each Treatment Visit, subjects will undergo efficacy assessments and safety procedures.
During the Washout and Treatment Phases subjects will complete the 'average pain' Numeric
Pain Rating Scale (NPRS) and count of rescue medication used for the preceding 24 hours.
Subjects will return 2 weeks after their last Treatment Visit (for a Follow-Up Visit).
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03277066 -
A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis
|
Phase 2 | |
| Recruiting |
NCT03090698 -
Outcomes of Injections in Patients Waiting for Total Knee Replacement
|
Phase 4 | |
| Completed |
NCT02556710 -
A Study to Evaluate the Efficacy & Safety of an Intra-Articular Ampion Injection for Pain of Osteoarthritis of the Knee
|
Phase 3 | |
| Completed |
NCT02242435 -
A Multiple Injection Study Evaluating Safety and Efficacy of Ampion in Osteoarthritis
|
Phase 3 | |
| Withdrawn |
NCT02237846 -
Clinical Study of Umbilical Cord Tissue Mesenchymal Stem Cells (UC-MSC) for Treatment of Osteoarthritis
|
Phase 1/Phase 2 | |
| Completed |
NCT02096393 -
Patient Specific Instrumentation in TKR
|
N/A | |
| Completed |
NCT01849445 -
Targeted Rehabilitation to Improve Outcome After Knee Replacement- A Physiotherapy Study
|
N/A | |
| Completed |
NCT01704157 -
A Prospective Study Evaluating the Treatment of Knee Osteoarthritis With the Cryo-Touch III Device
|
N/A | |
| Active, not recruiting |
NCT01374230 -
Long-Term Multicenter Evaluation of the E1® Tibial Bearing
|
N/A | |
| Not yet recruiting |
NCT01270412 -
Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis
|
Phase 2/Phase 3 | |
| Completed |
NCT02156440 -
Cross-over Study of the Efficacy and Safety of SierraSil Joint Formula 14 in Osteoarthritis of the Knee
|
Phase 2 | |
| Completed |
NCT01410409 -
Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement
|
N/A | |
| Completed |
NCT01207115 -
A Study of ABT-652 in Adults With Osteoarthritis Pain of the Knee
|
Phase 2 | |
| Completed |
NCT00970008 -
Exploring Massage Benefits for Arthritis of the Knee
|
Phase 2 | |
| Completed |
NCT00988091 -
Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee
|
Phase 3 | |
| Completed |
NCT01331278 -
A Comparative Study of Knee Systems
|
Phase 4 | |
| Completed |
NCT00792727 -
HKT-500 in Adult Patients With Osteoarthritis (OA) Knee Pain
|
Phase 3 | |
| Completed |
NCT00531427 -
Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee
|
Phase 3 | |
| Completed |
NCT00449696 -
Gel-200 Versus Placebo in Osteoarthritis of the Knee
|
Phase 3 | |
| Completed |
NCT04145011 -
Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain
|
N/A |