Osteoarthritis of Knee Clinical Trial
Official title:
A Randomized, Double Blind, Two Arms, Controlled Phase I/II Safety and Efficacy Study on MesoCellA-Ortho Tissue Engineered Product Intraarticularly Administrated in Adult Patients With Osteoarthrosis
The aim of the study is to evaluate safety, tolerability and clinical efficacy of a newly developed MesoCellA-Ortho tissue-engineered advanced therapy medicinal product in adult patients suffering with osteoarthritis and additionally burdened with other civilisation diseases such as type 2 diabetes and/ or obesity. The active substance of MesoCellA-Ortho consists of in vitro expanded autologous human adipose tissue-derived mesenchymal stem/ stromal cells (AT-MSCs) resuspended in carrier solution for intraarticular injections for individual patents.
To evaluate safety, tolerability and clinical efficacy of a MesoCellA-Ortho product, the active substance of MesoCellA-Ortho consisting of 20 mln in vitro expanded autologous human adipose tissue-derived mesenchymal stem/ stromal cells (AT-MSCs) will be intraarticularly administrated in adult patients with osteoarthritis and additionally burdened with other civilisation diseases such as type 2 diabetes and/ or obesity. Hyaluronic acid (HA) will be used as a Control. The safety and clinical outcome of the treatment will be evaluated during 6 months of followup, considering patient's subjective pain level and evaluation of the improvement of knee joint function. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT03274713 -
Efficacy of Electro-acupuncture Versus Manual Acupuncture on Knee Osteoarthritis
|
N/A | |
| Completed |
NCT04535596 -
Blood Flow Restriction Exercises and Conservative Exercises in Knee Osteoarthritis
|
N/A | |
| Completed |
NCT03918291 -
Whole-body Vibration Training on Functional Performance of the Elderly With Knee Osteoarthritis
|
N/A | |
| Recruiting |
NCT06263517 -
Clinical Trial to Assess Efficacy, Tolerability of Rising Doses of Clodronate in Painful Knee Osteoarthritis Patients
|
Phase 2/Phase 3 | |
| Completed |
NCT01453738 -
Allogeneic Mesenchymal Stem Cells in Osteoarthritis
|
Phase 2 | |
| Active, not recruiting |
NCT01027819 -
Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty
|
Phase 4 | |
| Completed |
NCT01186211 -
Feasibility of Outpatient Total Knee Arthroplasty
|
||
| Active, not recruiting |
NCT00261066 -
Outcome Following Orthopaedic Surgery
|
||
| Completed |
NCT03484910 -
Biofeedback With Cycling Exercise in OA Knee Patients
|
N/A | |
| Recruiting |
NCT03884374 -
Pain Relief for OsteoArthritis Through Combined Treatment (PROACT)
|
N/A | |
| Completed |
NCT03492320 -
Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty
|
||
| Completed |
NCT01449552 -
Temporary Clamping of Drains Combined With Tranexamic Acid Reduce Blood Loss After TKA: A Prospective RCT
|
N/A | |
| Completed |
NCT06254976 -
Serum Nesfatin-1 and Human Cartilage Glycoprotein-39 Levels in Knee Osteoarthritis
|
N/A | |
| Completed |
NCT03428893 -
Mobile Technology to Support Physical Therapy Exercise
|
N/A | |
| Completed |
NCT02850068 -
Geniculate Artery Embolization for the Treatment of Knee Pain
|
N/A | |
| Active, not recruiting |
NCT03110172 -
Short-term Efficacy of Antidepressant in Patients Underwent TKA
|
Phase 1/Phase 2 | |
| Enrolling by invitation |
NCT02623660 -
Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery
|
N/A | |
| Completed |
NCT02579174 -
Total Knee Replacement Component Alignment Using Manual Versus Custom Instrumentation
|
N/A | |
| Completed |
NCT00790985 -
Efficacy of Flavocoxid 500 mg Compared With Naproxen 500 mg in Subjects With Moderate-severe Osteoarthritis of the Knee
|
N/A | |
| Recruiting |
NCT02722811 -
Efficacy of Subcutaneous Injection of Etanercept for Moderate and Severe Knee Osteoarthritis
|
N/A |