Osteoarthritis, Obesity Clinical Trial
Official title:
Ultrasound Assessment of the Adventitia, Extra-media (EMT) and Veia Jugularis Interna Thickness in Obese Subjects Following a Significant Weight Loss
This is a substudy to a randomised trial investigating the effect of liraglutide on body
weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864). In
the parent trial, patients will be subjected to an 8-week diet intervention phase including a
low-calorie diet and dietetic counseling, after which patients will be randomised to receive
either liraglutide 3 mg or liraglutide 3 mg placebo as an add-on to dietetic guidance on
re-introducing regular foods and a focus on continued motivation to engage in a healthy
lifestyle.
This substudy aims to investigate any changes in the thickness of Adventitia, Extra-media
(EMT) and veia jugularis assessed by ultrasound in relation to an initial 8-week weight loss
intervention.
Change will be assessed by grey-scale ultrasound, the area measured will be from the anterior
wall of arteria carotis interna to the jugular vein including the wall of the vein,
subsequent the thickness of the artery will be subtracted to measure the thickness of the of
Adventitia, Extra-media (EMT) and veia jugularis interna compelx.
n/a