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Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty — CORK  

Osteoarthritis, Knee Clinical Trial

Official title:
Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty - a Randomized, Two by Two Factorial, Double-blind, Placebo-controlled Clinical Trial

Clinical Trial Summary

The goal of this study is to better understand how daily treatment with cannabidiol (CBD) affects the need for opioid pain medication, as well as pain, inflammation and other related symptoms, after knee replacement surgery. The information collected in this study is necessary to help understand whether CBD may be a useful medication before and/or after surgery. The study hypothesis is that CBD exerts opioid-sparing effects through anti-inflammatory, analgesic, and anxiolytic mechanisms.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06234631
Study type Interventional
Source University of Michigan
Contact Kendall Dubois
Phone 734-232-0324
Email kendalld@med.umich.edu
Status Recruiting
Phase Phase 2
Start date March 13, 2024
Completion date January 2029
View Details
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