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Bioavailability and Pharmacokinetic Measures of H. Procumbens Extract

Osteoarthritis, Knee Clinical Trial

Official title:
Study to Establish the Bioavailability and Pharmacokinetic Measures of H. Procumbens Extract in Humans

Clinical Trial Summary

Study will define the bioavailability and short term pharmacokinetics of the principal secondary metabolites of a aqueous-ethanolic extract of H. procumbens in non-enteric and enteric capsules.

Clinical Trial Description

The study(n = 12) will use a one-dose design to measure bioavailability and pharmacokinetic properties of an aqueous extract of H. procumbens containing 100mg harpagoside. Plasma levels of harpagoside, harpagide, verbascoside, and 8-p-coumarylharpagide will be measured for 24 hours with blood collections taken at timed intervals. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03641248
Study type Interventional
Source University of Missouri-Columbia
Contact
Status Withdrawn
Phase Early Phase 1
Start date May 1, 2021
Completion date August 31, 2021
View Details
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