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S-Asenosyl-L-Methionine vs Placebo for Osteoarthritis of the Hands — SAMe  

Osteoarthritis Hand Clinical Trial

Official title:
S-Adenosyl-L-Methionine (SAMe) vs Placebo for Discomfort and Functional Limitations Associated With Osteoarthritis of the Hands: a Pilot Study

Clinical Trial Summary

The primary objective of this study is to demonstrate the feasibility of evaluating SAMe tolerability, analgesic benefits, and daily functional improvement in patients with osteoarthritis of the hands compared to placebo. The secondary objective of this study is to generate preliminary data on discomfort, function, quality of life in patients with osteoarthritis of the hands when taking SAMe compared to placebo.

Clinical Trial Description

At week 0, all patients giving written informed consent and meeting eligibility requirements will be randomized in a double-blind manner (participant and investigator) in a 1:1 ratio to SAMe (400mg orally, twice daily) or placebo (400mg, twice daily) for 8 weeks. Followed by a one week wash out period followed by another 8 weeks of SAMe (400mg, twice daily) or placebo (400mg, twice daily) for 8 weeks (whichever was not given during the first 8 week period). Participants will complete weekly surveys during the entire study regarding hand discomfort, functional limitations and side effects ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05363020
Study type Interventional
Source Dartmouth-Hitchcock Medical Center
Contact
Status Active, not recruiting
Phase Phase 4
Start date August 17, 2022
Completion date August 1, 2024
View Details
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