Clinical Trials Logo
  1. Home
  2. Osteo Arthritis Knee
  3. NCT06130956

The Effect of a 2-week Preoperative Vegan Diet Versus Omnivorous Diet on the Protein Turnover in the Osteoarthritic Knee — KneeT-vegan  

Osteo Arthritis Knee Clinical Trial

Official title:
The Effect of a 2-week Preoperative Vegan Diet Versus Omnivorous Diet on the Protein Turnover in the Osteoarthritic Knee

Clinical Trial Summary

Rationale: Protein from plant-based foods may be unable to stimulate protein synthesis due to a suboptimal essential amino acid content and a lower digestibility. However, a more optimal amino acid profile may be achieved by increasing portions sizes and blending multiple plant-based sources. Studies investigating the anabolic properties of vegan diets (total elimination of animal-based foods) rather than single plant-based foods in older adults are scarce. It remains unknown if a vegan diet can also affect protein synthesis rates in other musculoskeletal tissues than muscle. Primary objective: To assess the effects of a 2-week preoperative vegan diet in comparison to an omnivorous diet on protein synthesis rates in Hoffa's fat pad, synovium, tendon, bone, ligaments, menisci, and cartilage in older adults with knee osteoarthritis undergoing total knee arthroplasty. Secondary objective: To assess the effects of a 2-week preoperative vegan diet in comparison to an omnivorous diet on blood pressure and plasma amino acids in older adults with knee osteoarthritis undergoing total knee arthroplasty. Study design: Multi-center, randomized, controlled trial with an intervention and a control group. Study population: 40 older adults (60 - 80 years) with osteoarthritis of the knee undergoing total knee replacement. Intervention: Controlled vegan diet versus controlled omnivorous diet, for a duration of 14 days. Main study parameters/endpoints: Primary study parameters are protein synthesis rates of Hoffa's fat pad, synovium, tendon, bone, ligament, menisci, and cartilage. Secondary parameters include blood pressure and plasma amino acids.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06130956
Study type Interventional
Source Wageningen University
Contact Inge Groenendijk, PhD
Phone +31628748271
Email inge.groenendijk@wur.nl
Status Not yet recruiting
Phase N/A
Start date May 1, 2024
Completion date February 28, 2025
View Details
See also
  Status Clinical Trial Phase
Terminated NCT04040985 - Legion Primary Safety and Efficacy N/A
Active, not recruiting NCT04525950 - Robotized Navigation Compared to Conventional Technique in Total Knee Replacement N/A
Recruiting NCT04320914 - High Intensity Laser Therapy (Classes IV) and Ibuprofen Gel Phonophoresis for Treating Knee Osteoarthritis N/A
Completed NCT03886142 - Platelet Rich Plasma Versus Radio Frequency for Chronic Knee Arthritis N/A
Terminated NCT04072055 - MOTO Post-marketing Surveillance Study
Not yet recruiting NCT06385275 - The Role of Vitamin K on Knee Osteoarthritis Outcomes Phase 1/Phase 2
Not yet recruiting NCT05290818 - Total Versus Robotic Assisted Unicompartmental Knee Replacement N/A
Withdrawn NCT03271229 - Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee Phase 2
Recruiting NCT05505552 - Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis: N/A
Recruiting NCT05992038 - Use of a Putty as Gap Filler in Open-wedge Osteotomy N/A
Recruiting NCT06066684 - Pain Phenotyping in Knee OA: a Pilot Trial
Completed NCT03847324 - Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty N/A
Recruiting NCT05126485 - Biofeedback Retention in Individuals With AKA Early Phase 1
Completed NCT04956393 - The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study N/A
Recruiting NCT04541342 - Arthroscopic Evaluation of Cartilage Regeneration After Opening-wedge High Tibial Osteotomy N/A
Completed NCT04391842 - Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis Phase 1
Completed NCT03680807 - Power Production in Older Adults With Knee Osteoarthritis
Completed NCT03783455 - Effectiveness of Five Intraarticular Strategies on Knee Osteoarthritis N/A
Not yet recruiting NCT06264362 - Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia N/A
Completed NCT05089253 - Effect of Physical Therapy Modalities in Osteoarthritis N/A