Tranexamic Acid in Total Knee Replacement

Status Completed

Clinical Trial Summary

Multiple intravenous Tranexamic Acid doses can reduce postoperative blood loss and improve the functional outcome in total knee arthroplasty without tourniquet: a randomized controlled study.

Clinical Trial Description

A total of 180 patients undergoing TKA for knee osteoarthritis were stratified in three equal groups. All surgeries were performed under spinal anesthesia, without tourniquet and patients should be in agreement with the established inclusion/exclusion criteria. Group A (60 patients) received 1g of IV TXA, Group B (60 patients) received an additional dose of IV TXA and Group C (60 patients) received three doses of IV TXA. The measured outcomes were the Hemoglobin (Hb) decrease, the transfusion rate, the functional, quality of life (QoL) and pain assessment based on their corresponding scoring system. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03656445
Study type	Interventional
Source	Democritus University of Thrace
Contact
Status	Completed
Phase	N/A
Start date	October 1, 2015
Completion date	March 31, 2017

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