Clinical Trials Logo
  1. Home
  2. Orthostatic Intolerance
  3. NCT01498809

Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury

Orthostatic Intolerance Clinical Trial

Official title:
Neural and Mechanical Baroreflex Sensitivity and Cerebral Blood Flow

Clinical Trial Summary

This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury. Midodrine has been shown to improve orthostatic symptoms in those with spinal cord injury but the physiological mechanisms influenced have not been identified. The investigators will examine key physiological components influencing orthostatic tolerance. The investigators will do this, by measuring the baroreflex, and brain blood flow autoregulation (the ability to maintain brain blood flow) before during and after the sit-up test. Two sit-up tests will occur; one before Midodrine administration, and one after administration of a 10mg dose of Midodrine.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01498809
Study type Observational
Source University of British Columbia
Contact
Status Completed
Phase
Start date March 2012
Completion date November 2013
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05529147 - The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
Recruiting NCT05555771 - Paediatric Syncope in the Emergency Department N/A
Completed NCT00770484 - Effect of Exercise in OI N/A
Completed NCT03743116 - Postoperative Orthostatic Intolerance and Hypotension in Unilateral TKA
Recruiting NCT04632134 - Long-term Effects of Transcutaneous Vagal Nerve Stimulation on Postural Orthostatic Tachycardia Syndrome (POTS) N/A
Completed NCT00685919 - Peripheral Dopamine in Postural Tachycardia Syndrome Phase 2/Phase 3
Not yet recruiting NCT05977335 - Continuous and Non-invasive Measurements by Task Force® CORE/CARDIO in Autonomic Function Testing (AFT)
Recruiting NCT06289413 - Autonomic Dysfunction in Patients Following Bariatric Surgery: The ADiPOSE Study
Recruiting NCT03759574 - Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty (THA)
Completed NCT03032328 - Vitamin D Deficiency and Dysautonomia N/A
Completed NCT02167412 - EEG Characteristics in Youth POTS and/or Syncope
Active, not recruiting NCT00692471 - Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)
Active, not recruiting NCT05990907 - Influence of RIC on the Orthostatic Competence of the Microcirculation N/A
Active, not recruiting NCT03970551 - Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension N/A
Completed NCT03808740 - Orthostatic Intolerance After Bariatric Surgery Phase 1
Completed NCT03261570 - Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS Early Phase 1
Terminated NCT00581477 - Treatment of Orthostatic Hypotension Phase 2/Phase 3
Enrolling by invitation NCT02725060 - Autoimmune Basis for Postural Tachycardia Syndrome N/A
Active, not recruiting NCT00581633 - Acute Salt Handling in Orthostatic Intolerance N/A
Completed NCT01153581 - Sex Hormones and Orthostatic Tolerance Phase 2