Acute Salt Handling in Orthostatic Intolerance

Status Active, not recruiting

Clinical Trial Summary

The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control subjects.

Clinical Trial Description

Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that regulate salt & water handling. Increases in dietary salt have salutary effects on orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt suggests abnormal salt handling in patients with chronic OI in a few patients. These data need to be confirmed and a better understanding of sodium handling in response to acute salt loads is required in these patients. ;

Study Design

Related Conditions & MeSH terms

Orthostatic Intolerance
Orthostatic Tachycardia
Postural Orthostatic Tachycardia Syndrome
Postural Tachycardia Syndrome
Tachycardia

Clinical Trial Details

NCT number	NCT00581633
Study type	Interventional
Source	Vanderbilt University Medical Center
Contact
Status	Active, not recruiting
Phase	N/A
Start date	February 2007
Completion date	December 2025

View Details

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