Clinical Trials Logo
  1. Home
  2. Orthostatic Hypotension
  3. NCT04902222

Orthostatic Intolerance and Hypotension After Administration of Morphine in Patients Prior to Hip or Knee Arthroplasty

Orthostatic Hypotension Clinical Trial

Official title:
Incidence of Orthostatic Intolerance and Orthostatic Hypotension After Administration of Intravenous Morphine in Patients Prior to Hip or Knee Arthroplasty

Clinical Trial Summary

Incidence of orthostatic intolerance and orthostatic hypotension after intravenous administration of morphine in patients prior to hip or knee arthroplasty.

Clinical Trial Description

Early postoperative mobilization is crucial for recovery of patients undergoing surgery in the multimodal fast-track approach to perioperative care, since physical immobilization is highly associated with increased risk of postoperative complications and prolonged hospital length of stay. Postoperative mobilization is often delayed due to patients experiencing orthostatic hypotension (OH), defined as a drop in systolic blood pressure > 20 mmHg or diastolic blood pressure > 10 mmHg, or orthostatic intolerance (OI), characterized by dizziness, blurred vision, nausea, vomiting, sensation of heat or syncope. Previous studies have found a high incidence of postoperative OI (> 40 %) among patients undergoing total hip arthroplasty. A possible causative factor to the high occurrence of OH and OI after surgery could be postoperative pain management by administration of morphine. Morphine is known to have many side-effects including nausea, vomiting, dizziness and orthostatic hypotension. The object of this study is to isolate and estimate the effect of intravenous morphine on the incidence of OH and OI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04902222
Study type Observational
Source Copenhagen University Hospital, Hvidovre
Contact Bodil Uldall-Hansen, BA Medicine
Phone +4528342057
Email bodil.uldall-hansen@regionh.dk
Status Recruiting
Phase
Start date April 1, 2021
Completion date May 1, 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT02705755 - TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) Phase 2
Recruiting NCT05941819 - ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury N/A
Recruiting NCT05529147 - The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
Recruiting NCT02897063 - Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Phase 1
Completed NCT02726776 - Suspension Syndrome N/A
Completed NCT01559675 - Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery N/A
Not yet recruiting NCT04440085 - RaGuS Trial by Postoperative Patients Phase 4
Recruiting NCT03732716 - Sarcopenia and Orthostatic Hypotension
Recruiting NCT05621460 - The Effect of Water Carbonation on Orthostatic Tolerance N/A
Completed NCT02632318 - Dawn Simulation and Postural Hypotension Phase 4
Completed NCT05729724 - Effect of Pharmacological Interventions on Systolic Blood Pressure Drops (SynABPM 2 Proof-of-concept)
Completed NCT03721393 - Data Collection - Of Syncope Tilt Table Testing Study
Completed NCT01030874 - Orthostatic Hypotension Treatment on Rehab Unit N/A
Completed NCT01362751 - Orthostatic Hypotension in Elderly Nursing Home Residents N/A
Completed NCT01223391 - Abdominal Compression in Orthostatic Hypotension N/A
Completed NCT00248807 - A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury. N/A
Terminated NCT00137319 - Impedance Threshold Device Tilt Study N/A
Completed NCT05233865 - Hemodynamic Effects During Land vs Water Exercise for Older Adults With Orthostatic Hypotension N/A
Suspended NCT01370512 - Droxidopa / Pyridostigmine in Orthostatic Hypotension Phase 2
Recruiting NCT00452712 - Orthostatic Hypotension in Children With Acute Febrile Illness Phase 2