Orthostatic Hypotension Clinical Trial
Official title:
RANDOMIZED CASE-CONTROLLED TRIAL ASSESSING MIDODRINE (GUTRON®) IN POSTOPERATIVE VASOPLEGIC PATIENTS
Vasoplegic syndrome is characterized clinically by reduced systemic vascular resistance and
normal or increased cardiac output. It is principally observed in cardiovascular and
orthopedic interventions and is characterized by a systemic inflammatory response with the
inability of the vascular endothelial muscles to contract and a resistance to the action of
vasoactive drugs. This event extends the length of stay in the critical care area due to the
need of vasoactive drugs.
The investigators aim to assess the standardized application of midodrine in postoperative
patients without sepsis and need of vasoactive drugs in order to reduce the length of stay in
critical care area and for extension in hospital.
Midodrine is an alpha 1 receptor agonist used usually in cases of hypotension helping to
increase blood pressure. The main indication is orthostatic hypotension but there are other
clinical conditions where this medicament is often used like hypotension by dialysis,
hepatorenal syndrome and after carotid artery stenting.
Vasoplegic syndrome coul be interpreted as a variant of orthostatic hypotension that happens
usually after surgical interventions. It produces a loss of systemic vascular resistance due
to inflammatory reaction without any signs of infection.
The investigators aim to conduct a randomized, double-blind, single-center,
placebo-controlled study of midodrine in patients who present postoperative vasoplegia with
no active signs of sepsis but need of vasoactive drugs (Noradrenalin).
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