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Orthodontic Appliances, Fixed clinical trials

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NCT ID: NCT05147376 Completed - Oral Ulcer Clinical Trials

Effectiveness of a Curcumin Mouthwash in Preventing Traumatic Ulcers in Patients With Fixed Orthodontic Appliances

Start date: February 21, 2022
Phase: Early Phase 1
Study type: Interventional

The study is a randomized controlled trial. The participants will be equally allocated into 2 groups to compare clinical effectiveness of curcumin mouthwash in fixed orthodontic patients during the first month of treatment.

NCT ID: NCT04395625 Active, not recruiting - Clinical trials for Orthodontic Appliances, Fixed

Computer-aided Indirect Bonding Versus Traditional Direct Bonding of Brackets in Orthodontic Patients

Start date: April 30, 2015
Phase: N/A
Study type: Interventional

Accurate bracket positioning is one of the keys for effective orthodontic treatment. Traditionally, orthodontic brackets are positioned one-by-one on the teeth of the patient, with the so-called direct bonding method. In the past, the term indirect bonding defined a technique where the brackets were positioned on a plaster model in order to increase placement precision. A transfer tray was then built on the plaster, incorporating all the brackets mounted. Finally, this transfer tray was positioned in the mouth of the patient, so that all the brackets could be bonded to the teeth at once in the pre-determined position. Several studies have investigated this indirect technique based on plaster models. With computer-aided technology, a new form of digital indirect bonding is now possible. The dentist digitally places the brackets on a virtual 3D model of the teeth. A tray with the brackets' positioning information is then generated with CAD-CAM (computer aided design and manufacturing) technology and the brackets are subsequently indirectly transferred to the teeth. This new approach could possibly save chair time and increase precision. Our profession is today moving towards the virtual reality, and application of such a computer-aided technology method into the clinical work-flow seems definitely promising for our future daily practice. Since the evidence about this new computer-assisted indirect bracket bonding method is very limited, the purpose of this study is to evaluate precision, chair time, and bracket survival by comparing this digital indirect bonding method to the traditional direct bonding method Specific objectives - To assess and compare the accuracy of a conventional direct bonding method with an indirect computer-aided bonding method. - To evaluate chair time and bracket survival related to both bonding methods. Hypothesis Null hypothesis: I. There is no difference in accuracy of bracket placement between the direct and indirect bonding methods. II. There is no difference in chair time between the two bonding methods. III. Bracket bond failure is similar for both bonding methods. Alternative hypothesis: I. Bracket placement is more precise/accurate with the indirect bonding method compared to the traditional direct bonding method. II. Indirect bonding reduces chair time.

NCT ID: NCT04139538 Active, not recruiting - Oral Microbiome Clinical Trials

Microbiome and Immunogenity of Saliva During Orthodontic Therapy

Start date: November 1, 2019
Phase: N/A
Study type: Interventional

There are two essential ways of treatment in the field of orthodontics. The fixed appliance treatment with self-ligating or conventional brackets and treatment with aligners. Fixed orthodontic treatment has been the optional therapy for decades. Due to an increasing demand of patients for a more aesthetic treatment, the number of aligner treatments multiplied over the last years. Within the last years, a crucial role of oral microbiome in the maintenance of oral health was largely appreciated. However, to date there is no data on the effect of different orthodontic treatments on the oral microbiome. The aim of the research project is the prospective comparison of the oral microbiome in saliva of adult patients treated with Invisalign® aligners or metal brackets. We plan to include a sample of twenty healthy individuals. Half of the participants will receive aligner treatment with Invisalign® and half metal brackets. Saliva will be collected before, 3 and 6 months after the beginning of the orthodontic therapy via a stimulated a saliva collection. The 16S rDNA genes will be amplified and sequenced with Illumina MiSeq® System. Probing depth, bleeding on probing and Plaque Index will be evaluated over time and correlated with changes of the oral microbiome.