Oropharyngeal Neoplasms Clinical Trial
Official title:
Impact of the Human Papillomavirus (HPV) Status in Carcinologic Prognosis of Oropharynx Squamous Cell Carcinoma.
High risk papillomavirus (HR-HPV) have an oncogenic role in Oropharyngeal squamous cell
carcinomas (OP-SCC) in at least 25% of the cases and the prevalence is increasing. HPV+
might be more chemo and radio sensible with a better prognosis (disease-free survival (DFS)
and overall survival (OS) as compared to HPV negative OP-SCC ; hypothesis : 2y DFS > 20%
improvement). The principal objective is to determine the impact of the status of HR-HPV in
the prognosis of the OP-SCC. The principal criteria is the 2-years DFS.
Secondary objective : virologic characteristics of HPV+ tumors.
The study has no impact on the treatment of the observed population. The clinical study include TNM status, previous story of HPV infection, smoking and alcoholic habits, treatment and outcome during 5 years. The virologic study include : HPV type, E6-E7 viral charge of HPV16, viral DNA integration in the tumoral genome, HPV16 variants, expression of HPV 16, 18, 31, 45 coding oncoproteins E6-E7 mRNA. Moreover a serologic study will be done. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03239834 -
Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making
|
||
| Recruiting |
NCT00251381 -
Cetuximab & Concomitant-Boost Accelerated RT in Patients With Locally Advanced Oropharynx Squamous Cell Carcinoma.
|
Phase 2 | |
| Completed |
NCT03074110 -
Isocapnic Hyperventilation - an Alternative Method
|
N/A | |
| Enrolling by invitation |
NCT04266093 -
Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies
|
||
| Recruiting |
NCT02792322 -
Robotic Surgery in the Seated Position for Benign and Malignant Lesions of the Head and Neck
|
N/A | |
| Recruiting |
NCT05412628 -
Investigating the Association Between Microbiota and Esophageal/Oropharyngeal Cancer
|
N/A | |
| Recruiting |
NCT04124198 -
Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma
|
N/A | |
| Completed |
NCT00721799 -
F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients
|
Phase 2 | |
| Recruiting |
NCT00181038 -
Analgesia of Fibula Free Flap Donor Site by Peri-Neuronal Catheter in Oro-Pharyngeal Carcinoma Surgery
|
Phase 3 | |
| Terminated |
NCT04015336 -
E7 TCR Cell Induction Immunotherapy for Stage II and Stage III HPV-Associated Oropharyngeal Cancer
|
Phase 2 | |
| Withdrawn |
NCT04044950 -
A Phase II Study of Neoadjuvant E7 TCR T Cell Immunotherapy for Borderline Resectable and Unresectable Stage I HPV-Associated Oropharyngeal Cancer
|
Phase 2 | |
| Completed |
NCT02262247 -
A Post-Market Clinical Trial for Access and Visualization of the Oropharynx, Hypopharynx and Larynx During Transoral Procedures
|
N/A | |
| Terminated |
NCT01687413 -
Post Operative Adjuvant Therapy De-intensification Trial for Human Papillomavirus-related, p16+ Oropharynx Cancer
|
Phase 3 | |
| Completed |
NCT01530997 -
De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca
|
Phase 2 | |
| Completed |
NCT03010813 -
A Novel Robotic System for Single Port and Natural Orifice Transluminal Endoscopic Surgery
|
N/A | |
| Completed |
NCT03077243 -
P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC
|
Phase 2 | |
| Terminated |
NCT02045186 -
Monitoring of Oral Human Papillomavirus Infection (HPV) in HPV-positive Oropharyngeal Squamous Cell Carcinoma (OPSCC)
|
N/A | |
| Withdrawn |
NCT02298595 -
Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT02281955 -
De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study
|
Phase 2 | |
| Terminated |
NCT01525927 -
Study of Chemotherapy Prior to Radiotherapy and Chemotherapy in Patients With HPV Associated Cancer of the Oral Cavity
|
Phase 2 |