Temporomandibular Disorders Clinical Trial
Official title:
Genetic Polymorphisms and Their Association With Temporomandibular Disorders
Temporomandibular disorders (TMD) are the most common orofacial pain disorders of non-dental origin with the prevalence of 6.1-10.2%, and incidence of 3.9%. Observable pathology is mostly absent, and the etiology often remains unknown. Since some other painful conditions of unknown origin (eg. fibromyalgia), also imply genetic factors, the aim of the study is to investigate genetic predisposition in relation to the risk for TMD onset. This will be achieved through analysis of polymorphisms in the selected genes in TMD patients (DC/TMD) and matched control subjects. The possibility of involvement of specific polymorphisms in modulation of therapy response will also be investigated. The hypotheses: (I) the Single Nucleotide Polymorphism (SNPs) clustering will be dependent on presence or absence of TMD (comparison of patients with control subjects), and will possibly depend on source of pain, pain intensity, presence of bone changes, psychological features and previous orthodontic therapy, and (II) SNPs will influence the treatment response. Along with anamnestic and clinical examination and occlusal splint therapy, genomic DNA will be analyzed from the buccal swabs. Isolated DNA will be used for the determination of 19 polymorphisms of selected genes using Real-Time PCR method. The analysis of salivary oxidative stress markers and opiorphin will be also performed, as their relationship with TMD has been shown previously. This time, their concentration will be associated with polymorphisms in the promoters of genes responsible for their synthesis. The investigators expect to show that particular gene profile or group of SNPs represent a risk factor for TMD development. Innovative approach of the concept of determining the genetic predisposition for TMD has the potential for development of commercial genetic test with potential for risk estimation in relation to TMD onset. This could enable early interventions and active avoidance of environmental risk factors.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02839967 -
Influence of Intraoral Photobiomodulation in Individuals With Temporomandibular Joint Dysfunction
|
N/A | |
| Completed |
NCT01659840 -
Efficacy of Red and Infrared Lasers in Treatment of Temporomandibular Disorders
|
N/A | |
| Recruiting |
NCT05720065 -
Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A
|
Phase 2 | |
| Completed |
NCT03339739 -
Effects of Mandibular Exercises Effect on Pain Perception and Sensitivity in Mandibular Myofascial Pain
|
N/A | |
| Recruiting |
NCT03029494 -
Oxidative Stress and Opiorphin in Temporomandibular Disorders
|
N/A | |
| Completed |
NCT05607823 -
Adding Core Stabilization Training to Manuel Therapy in Temporomandibular Disorders
|
N/A | |
| Completed |
NCT04948320 -
Temporomandibular Dysfunction Affects Neck Disability, Headache, Anxiety, And Sleep Quality In Women: A Cross-Sectional Study
|
||
| Recruiting |
NCT04726683 -
Dry Needling vs Injection in Patients With Temporomandibular Disorders
|
N/A | |
| Completed |
NCT01201512 -
CONDOR Temporomandibular Muscle and Joint Disorders (TMJD) Survey
|
N/A | |
| Completed |
NCT04098952 -
Effects of Electric Massage on the Cervical Region in Subjects Diagnosed With Temporomandibular Disorders
|
N/A | |
| Terminated |
NCT05162027 -
Erenumab-aooe for Temporomandibular Disorders Management: TMD Cgrp Antibody RElief (TMD CARE)
|
Phase 2 | |
| Completed |
NCT03926767 -
Additional Effect of Pain Neuroscience Education to Orofacial and Neck Exercises in Temporomandibular Disorders
|
N/A | |
| Recruiting |
NCT05902026 -
The BETY-Biopsychosocial Questionnaire (BETY-BQ) in Individuals With Temporomandibular Dysfunction-Related Headache
|
||
| Completed |
NCT03736408 -
Frequency of Occurrence of the Pain Form of Temporomandibular Joint Dysfunction
|
||
| Recruiting |
NCT01544439 -
Occlusal Splint and Counseling to Temporomandibular Disorder
|
Phase 3 | |
| Completed |
NCT02380105 -
Effectiveness of a Counseling Program for Temporomandibular Disorders (TMD) Treatment
|
N/A | |
| Completed |
NCT01535378 -
Interest of Behavioural Reeducation in Dysfunctions of Masticatory Apparatus. Relations Between Parafunctions and Dysfunctions of Mastixatory Apparatus
|
N/A | |
| Completed |
NCT02230371 -
Study on the Effect of Granisetron on Myofascial Pain in the Orofacial Muscles
|
Phase 4 | |
| Recruiting |
NCT03990662 -
What Are the Clinical Factors Associated With a Significant Pain Reduction Following Physiotherapy in Patients With Temporomandibular Disorders?
|
||
| Recruiting |
NCT05927545 -
Efficacy of Manuel Therapy and BETY in Patients With Temporomandibular Dysfunction Related Headache
|
N/A |